Effect of Adjustable Passive Constraint on the Failing Left Ventricle: A Finite-Element Model Study

Choon-Sik Jhun, Jonathan F. Wenk, Zhihong Zhang, Samuel T. Wall, Kay Sun, Hani N. Sabbah, Mark B. Ratcliffe, Julius M. Guccione

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Passive constraint is used to prevent left ventricular dilation and subsequent remodeling. However, there has been concern about the effect of passive constraint on diastolic left ventricular chamber stiffness and pump function. This study determined the relationship between constraint, diastolic wall stress, chamber stiffness, and pump function. We tested the hypothesis that passive constraint at 3 mm Hg reduces wall stress with minimal change in pump function. Methods: A three-dimensional finite-element model of the globally dilated left ventricle based on left ventricular dimensions obtained in dogs that had undergone serial intracoronary microsphere injection was created. The model was adjusted to match experimentally observed end-diastolic left ventricular volume and midventricular wall thickness. The experimental results used to create the model were previously reported. A pressure of 3, 5, 7, and 9 mm Hg was applied to the epicardium. Fiber stress, end-diastolic pressure-volume relationship, end-systolic pressure-volume relationship, and the stroke volume-end-diastolic pressure (Starling) relationship were calculated. Results: As epicardial constraint pressure increased, fiber stress decreased, the end-diastolic pressure-volume relationship shifted to the left, and the Starling relationship shifted down and to the right. The end-systolic pressure-volume relationship did not change. A constraining pressure of 2.3 mm Hg was associated with a 10% reduction in stroke volume, and mean end-diastolic fiber stress was reduced by 18.3% (inner wall), 15.3% (mid wall), and 14.2% (outer wall). Conclusions: Both stress and cardiac output decrease in a linear fashion as the amount of passive constraint is increased. If the reduction in cardiac output is to be less than 10%, passive constraint should not exceed 2.3 mm Hg. On the other hand, this amount of constraint may be sufficient to reverse eccentric hypertrophy after myocardial infarction.

Original languageEnglish (US)
Pages (from-to)132-137
Number of pages6
JournalAnnals of Thoracic Surgery
Volume89
Issue number1
DOIs
StatePublished - Jan 1 2010

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Heart Ventricles
Stress Fibers
Blood Pressure
Stroke Volume
Starlings
Pressure
Cardiac Output
Pericardium
Microspheres
Hypertrophy
Dilatation
Myocardial Infarction
Dogs
Injections

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Jhun, Choon-Sik ; Wenk, Jonathan F. ; Zhang, Zhihong ; Wall, Samuel T. ; Sun, Kay ; Sabbah, Hani N. ; Ratcliffe, Mark B. ; Guccione, Julius M. / Effect of Adjustable Passive Constraint on the Failing Left Ventricle : A Finite-Element Model Study. In: Annals of Thoracic Surgery. 2010 ; Vol. 89, No. 1. pp. 132-137.
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title = "Effect of Adjustable Passive Constraint on the Failing Left Ventricle: A Finite-Element Model Study",
abstract = "Background: Passive constraint is used to prevent left ventricular dilation and subsequent remodeling. However, there has been concern about the effect of passive constraint on diastolic left ventricular chamber stiffness and pump function. This study determined the relationship between constraint, diastolic wall stress, chamber stiffness, and pump function. We tested the hypothesis that passive constraint at 3 mm Hg reduces wall stress with minimal change in pump function. Methods: A three-dimensional finite-element model of the globally dilated left ventricle based on left ventricular dimensions obtained in dogs that had undergone serial intracoronary microsphere injection was created. The model was adjusted to match experimentally observed end-diastolic left ventricular volume and midventricular wall thickness. The experimental results used to create the model were previously reported. A pressure of 3, 5, 7, and 9 mm Hg was applied to the epicardium. Fiber stress, end-diastolic pressure-volume relationship, end-systolic pressure-volume relationship, and the stroke volume-end-diastolic pressure (Starling) relationship were calculated. Results: As epicardial constraint pressure increased, fiber stress decreased, the end-diastolic pressure-volume relationship shifted to the left, and the Starling relationship shifted down and to the right. The end-systolic pressure-volume relationship did not change. A constraining pressure of 2.3 mm Hg was associated with a 10{\%} reduction in stroke volume, and mean end-diastolic fiber stress was reduced by 18.3{\%} (inner wall), 15.3{\%} (mid wall), and 14.2{\%} (outer wall). Conclusions: Both stress and cardiac output decrease in a linear fashion as the amount of passive constraint is increased. If the reduction in cardiac output is to be less than 10{\%}, passive constraint should not exceed 2.3 mm Hg. On the other hand, this amount of constraint may be sufficient to reverse eccentric hypertrophy after myocardial infarction.",
author = "Choon-Sik Jhun and Wenk, {Jonathan F.} and Zhihong Zhang and Wall, {Samuel T.} and Kay Sun and Sabbah, {Hani N.} and Ratcliffe, {Mark B.} and Guccione, {Julius M.}",
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Jhun, C-S, Wenk, JF, Zhang, Z, Wall, ST, Sun, K, Sabbah, HN, Ratcliffe, MB & Guccione, JM 2010, 'Effect of Adjustable Passive Constraint on the Failing Left Ventricle: A Finite-Element Model Study', Annals of Thoracic Surgery, vol. 89, no. 1, pp. 132-137. https://doi.org/10.1016/j.athoracsur.2009.08.075

Effect of Adjustable Passive Constraint on the Failing Left Ventricle : A Finite-Element Model Study. / Jhun, Choon-Sik; Wenk, Jonathan F.; Zhang, Zhihong; Wall, Samuel T.; Sun, Kay; Sabbah, Hani N.; Ratcliffe, Mark B.; Guccione, Julius M.

In: Annals of Thoracic Surgery, Vol. 89, No. 1, 01.01.2010, p. 132-137.

Research output: Contribution to journalArticle

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T1 - Effect of Adjustable Passive Constraint on the Failing Left Ventricle

T2 - A Finite-Element Model Study

AU - Jhun, Choon-Sik

AU - Wenk, Jonathan F.

AU - Zhang, Zhihong

AU - Wall, Samuel T.

AU - Sun, Kay

AU - Sabbah, Hani N.

AU - Ratcliffe, Mark B.

AU - Guccione, Julius M.

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Y1 - 2010/1/1

N2 - Background: Passive constraint is used to prevent left ventricular dilation and subsequent remodeling. However, there has been concern about the effect of passive constraint on diastolic left ventricular chamber stiffness and pump function. This study determined the relationship between constraint, diastolic wall stress, chamber stiffness, and pump function. We tested the hypothesis that passive constraint at 3 mm Hg reduces wall stress with minimal change in pump function. Methods: A three-dimensional finite-element model of the globally dilated left ventricle based on left ventricular dimensions obtained in dogs that had undergone serial intracoronary microsphere injection was created. The model was adjusted to match experimentally observed end-diastolic left ventricular volume and midventricular wall thickness. The experimental results used to create the model were previously reported. A pressure of 3, 5, 7, and 9 mm Hg was applied to the epicardium. Fiber stress, end-diastolic pressure-volume relationship, end-systolic pressure-volume relationship, and the stroke volume-end-diastolic pressure (Starling) relationship were calculated. Results: As epicardial constraint pressure increased, fiber stress decreased, the end-diastolic pressure-volume relationship shifted to the left, and the Starling relationship shifted down and to the right. The end-systolic pressure-volume relationship did not change. A constraining pressure of 2.3 mm Hg was associated with a 10% reduction in stroke volume, and mean end-diastolic fiber stress was reduced by 18.3% (inner wall), 15.3% (mid wall), and 14.2% (outer wall). Conclusions: Both stress and cardiac output decrease in a linear fashion as the amount of passive constraint is increased. If the reduction in cardiac output is to be less than 10%, passive constraint should not exceed 2.3 mm Hg. On the other hand, this amount of constraint may be sufficient to reverse eccentric hypertrophy after myocardial infarction.

AB - Background: Passive constraint is used to prevent left ventricular dilation and subsequent remodeling. However, there has been concern about the effect of passive constraint on diastolic left ventricular chamber stiffness and pump function. This study determined the relationship between constraint, diastolic wall stress, chamber stiffness, and pump function. We tested the hypothesis that passive constraint at 3 mm Hg reduces wall stress with minimal change in pump function. Methods: A three-dimensional finite-element model of the globally dilated left ventricle based on left ventricular dimensions obtained in dogs that had undergone serial intracoronary microsphere injection was created. The model was adjusted to match experimentally observed end-diastolic left ventricular volume and midventricular wall thickness. The experimental results used to create the model were previously reported. A pressure of 3, 5, 7, and 9 mm Hg was applied to the epicardium. Fiber stress, end-diastolic pressure-volume relationship, end-systolic pressure-volume relationship, and the stroke volume-end-diastolic pressure (Starling) relationship were calculated. Results: As epicardial constraint pressure increased, fiber stress decreased, the end-diastolic pressure-volume relationship shifted to the left, and the Starling relationship shifted down and to the right. The end-systolic pressure-volume relationship did not change. A constraining pressure of 2.3 mm Hg was associated with a 10% reduction in stroke volume, and mean end-diastolic fiber stress was reduced by 18.3% (inner wall), 15.3% (mid wall), and 14.2% (outer wall). Conclusions: Both stress and cardiac output decrease in a linear fashion as the amount of passive constraint is increased. If the reduction in cardiac output is to be less than 10%, passive constraint should not exceed 2.3 mm Hg. On the other hand, this amount of constraint may be sufficient to reverse eccentric hypertrophy after myocardial infarction.

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