Effect of aspirin on prostaglandin synthesis by human platelets

Esmail Jafari, Abdus Saleem, Bahu S. Shaikh, Laurence M. Demers

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

When platelet rich plasma is exposed to N-ethylmaleimide, a ten fold increase in measurable prostaglandin E synthesis occurs. This effect is almost completely abolished within 2 hours of ingestion of 600 mg of aspirin by human volunteers. Recovery of this platelet function is slow for the first two days, returning sharply to normal over the next six days and plateauing approximately 8 days following initial removal from aspirin. It is suggested from these studies that platelet prostaglandin E production following NEM may be a useful test of platelet function.

Original languageEnglish (US)
Pages (from-to)829-835
Number of pages7
JournalProstaglandins
Volume12
Issue number5
DOIs
StatePublished - Nov 1976

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology

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