Effect of bethanechol and metoclopramide on upper gastrointestinal motility in the kitten

Craig Hillemeier, Richard McCallum, Robin Oertel, Joyce Gryboski

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Gastroesophageal reflux (GER) during infancy is a disorder of unknown etiology which may be associated with abnormalities of upper gastrointestinal motor function. Bethanechol, a muscarinic agonist, and metoclopramide, a dopamine antagonist, have been utilized as pharmacologic agents in an attempt to improve upper gastrointestinal motility in this disorder. We have studied the effect of these agents on upper gastrointestinal motility in an infant model, the kitten. Bethanechol is found to greatly increase lower esophageal sphincter (LES) pressure and have no effect on esophageal peristaltic amplitude or gastric emptying of a liquid meal. Metoclopramide causes a small and nonsignificant increase in LES pressure, has no effect on esophageal peristalsis, and increases the rate of gastric emptying of a liquid meal. These results suggest that these two agents may have specific actions on the infant’s upper gastrointestinal tract.

Original languageEnglish (US)
Pages (from-to)134-137
Number of pages4
JournalJournal of pediatric gastroenterology and nutrition
Volume5
Issue number1
DOIs
StatePublished - Jan 1986

Fingerprint

Bethanechol
Lower Esophageal Sphincter
Metoclopramide
Gastrointestinal Motility
Gastric Emptying
Meals
Pressure
Peristalsis
Muscarinic Agonists
Upper Gastrointestinal Tract
Dopamine Antagonists
Gastroesophageal Reflux

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Cite this

Hillemeier, Craig ; McCallum, Richard ; Oertel, Robin ; Gryboski, Joyce. / Effect of bethanechol and metoclopramide on upper gastrointestinal motility in the kitten. In: Journal of pediatric gastroenterology and nutrition. 1986 ; Vol. 5, No. 1. pp. 134-137.
@article{140dc35cca824f35b124df8516d50ac6,
title = "Effect of bethanechol and metoclopramide on upper gastrointestinal motility in the kitten",
abstract = "Gastroesophageal reflux (GER) during infancy is a disorder of unknown etiology which may be associated with abnormalities of upper gastrointestinal motor function. Bethanechol, a muscarinic agonist, and metoclopramide, a dopamine antagonist, have been utilized as pharmacologic agents in an attempt to improve upper gastrointestinal motility in this disorder. We have studied the effect of these agents on upper gastrointestinal motility in an infant model, the kitten. Bethanechol is found to greatly increase lower esophageal sphincter (LES) pressure and have no effect on esophageal peristaltic amplitude or gastric emptying of a liquid meal. Metoclopramide causes a small and nonsignificant increase in LES pressure, has no effect on esophageal peristalsis, and increases the rate of gastric emptying of a liquid meal. These results suggest that these two agents may have specific actions on the infant’s upper gastrointestinal tract.",
author = "Craig Hillemeier and Richard McCallum and Robin Oertel and Joyce Gryboski",
year = "1986",
month = "1",
doi = "10.1097/00005176-198601000-00025",
language = "English (US)",
volume = "5",
pages = "134--137",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

Effect of bethanechol and metoclopramide on upper gastrointestinal motility in the kitten. / Hillemeier, Craig; McCallum, Richard; Oertel, Robin; Gryboski, Joyce.

In: Journal of pediatric gastroenterology and nutrition, Vol. 5, No. 1, 01.1986, p. 134-137.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of bethanechol and metoclopramide on upper gastrointestinal motility in the kitten

AU - Hillemeier, Craig

AU - McCallum, Richard

AU - Oertel, Robin

AU - Gryboski, Joyce

PY - 1986/1

Y1 - 1986/1

N2 - Gastroesophageal reflux (GER) during infancy is a disorder of unknown etiology which may be associated with abnormalities of upper gastrointestinal motor function. Bethanechol, a muscarinic agonist, and metoclopramide, a dopamine antagonist, have been utilized as pharmacologic agents in an attempt to improve upper gastrointestinal motility in this disorder. We have studied the effect of these agents on upper gastrointestinal motility in an infant model, the kitten. Bethanechol is found to greatly increase lower esophageal sphincter (LES) pressure and have no effect on esophageal peristaltic amplitude or gastric emptying of a liquid meal. Metoclopramide causes a small and nonsignificant increase in LES pressure, has no effect on esophageal peristalsis, and increases the rate of gastric emptying of a liquid meal. These results suggest that these two agents may have specific actions on the infant’s upper gastrointestinal tract.

AB - Gastroesophageal reflux (GER) during infancy is a disorder of unknown etiology which may be associated with abnormalities of upper gastrointestinal motor function. Bethanechol, a muscarinic agonist, and metoclopramide, a dopamine antagonist, have been utilized as pharmacologic agents in an attempt to improve upper gastrointestinal motility in this disorder. We have studied the effect of these agents on upper gastrointestinal motility in an infant model, the kitten. Bethanechol is found to greatly increase lower esophageal sphincter (LES) pressure and have no effect on esophageal peristaltic amplitude or gastric emptying of a liquid meal. Metoclopramide causes a small and nonsignificant increase in LES pressure, has no effect on esophageal peristalsis, and increases the rate of gastric emptying of a liquid meal. These results suggest that these two agents may have specific actions on the infant’s upper gastrointestinal tract.

UR - http://www.scopus.com/inward/record.url?scp=0022904788&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022904788&partnerID=8YFLogxK

U2 - 10.1097/00005176-198601000-00025

DO - 10.1097/00005176-198601000-00025

M3 - Article

C2 - 2868086

AN - SCOPUS:0022904788

VL - 5

SP - 134

EP - 137

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 1

ER -