Effect of bethanechol and metoclopramide on upper gastrointestinal motility in the kitten

Craig Hillemeier, Richard McCallum, Robin Oertel, Joyce Gryboski

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Gastroesophageal reflux (GER) during infancy is a disorder of unknown etiology which may be associated with abnormalities of upper gastrointestinal motor function. Bethanechol, a muscarinic agonist, and metoclopramide, a dopamine antagonist, have been utilized as pharmacologic agents in an attempt to improve upper gastrointestinal motility in this disorder. We have studied the effect of these agents on upper gastrointestinal motility in an infant model, the kitten. Bethanechol is found to greatly increase lower esophageal sphincter (LES) pressure and have no effect on esophageal peristaltic amplitude or gastric emptying of a liquid meal. Metoclopramide causes a small and nonsignificant increase in LES pressure, has no effect on esophageal peristalsis, and increases the rate of gastric emptying of a liquid meal. These results suggest that these two agents may have specific actions on the infant’s upper gastrointestinal tract.

Original languageEnglish (US)
Pages (from-to)134-137
Number of pages4
JournalJournal of pediatric gastroenterology and nutrition
Volume5
Issue number1
DOIs
StatePublished - Jan 1986

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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