TY - JOUR
T1 - Effect of bleach on the transport characteristics of polysulfone hemodialyzers
AU - Wolff, Susanne H.
AU - Zydney, Andrew L.
N1 - Funding Information:
The authors would like to thank Justin Shaffer for his assistance with the dextran sieving experiments, Fresenius Medical Care for providing the hollow fiber dialyzers, and Fresenius Medical Care and Novaflux Technologies for their financial support.
PY - 2004/11/1
Y1 - 2004/11/1
N2 - Although post-treatment modifications are widely employed to increase hydrophilicity and render membranes more biocompatible, they can also be used to modify the membrane pore size. In this study, hollow fiber Fresenius membranes made from polysulfone and poly(vinyl pyrrolidone) (PVP) were treated with a hypochlorite (bleach) solution for different periods of time. X-ray photoelectron spectroscopy (XPS) demonstrated a significant loss of PVP, with the bulk of the PVP removal occurring within the first hour of bleach exposure. The bleach-treated membranes also had a greater negative charge and a larger effective pore size. In contrast to the XPS data, the membrane charge and pore size continued to increase throughout the 14 h bleach exposure. Hindered diffusion and sieving data were analyzed using available hydrodynamic models that account for the asymmetric structure of the hollow fiber membranes. The good agreement between the hydrodynamic model and data indicates that the bleach-treated membranes were free of any large defects.
AB - Although post-treatment modifications are widely employed to increase hydrophilicity and render membranes more biocompatible, they can also be used to modify the membrane pore size. In this study, hollow fiber Fresenius membranes made from polysulfone and poly(vinyl pyrrolidone) (PVP) were treated with a hypochlorite (bleach) solution for different periods of time. X-ray photoelectron spectroscopy (XPS) demonstrated a significant loss of PVP, with the bulk of the PVP removal occurring within the first hour of bleach exposure. The bleach-treated membranes also had a greater negative charge and a larger effective pore size. In contrast to the XPS data, the membrane charge and pore size continued to increase throughout the 14 h bleach exposure. Hindered diffusion and sieving data were analyzed using available hydrodynamic models that account for the asymmetric structure of the hollow fiber membranes. The good agreement between the hydrodynamic model and data indicates that the bleach-treated membranes were free of any large defects.
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U2 - 10.1016/j.memsci.2004.06.044
DO - 10.1016/j.memsci.2004.06.044
M3 - Article
AN - SCOPUS:23044466016
SN - 0376-7388
VL - 243
SP - 389
EP - 399
JO - Journal of Membrane Science
JF - Journal of Membrane Science
IS - 1-2
ER -