Effect of chlorpromazine and haloperidol on negative contrast

Charles F. Flaherty, Howard C. Becker, Susan Checke, Grace A. Rowan, Patricia "Sue" Grigson-Kennedy

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Rats shifted from 32 to 4% sucrose consume substantially less of the 4% solution than animals that have not had prior experience with the 32% sucrose. This negative contrast effect was not substantially influenced by chlorpromazine (1, 3, and 5 mg/kg) or haloperidol (0.1, 0.5, and 1.0 mg/kg). Haloperidol decreased overall lick frequency, but this decrease occurred proportionately in shifted and unshifted rats, leaving contrast intact. The benzodiazepine flurazepam (5, 10, and 20 mg/kg), included as a positive control, reduced contrast at the two highest doses. The results suggest thav neuroleptics do not disrupt consummatory contrast and that dopaminergic antagonists may not influence reward relativity.

Original languageEnglish (US)
Pages (from-to)111-117
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume42
Issue number1
DOIs
StatePublished - Jan 1 1992

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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