Effect of crosslinking and glycosaminoglycan depletion on the extra-fibrillar matrix mechanics of annulus fibrosus

Daniel Humbe Cortes Correales, Joseph Chiaro, Lachlan J. Smith, Dawn M. Elliott

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Protein crosslinking and glycosaminoglycan (GAG) depletion are characteristic of disc degeneration. The objective of this study is to analyze the role of these biochemical changes on the mechanics of annulus fibrosus extra-fibrillar matrix (EFM). It was found that GAG depletion decreased ionic contribution, but not the nonionic contribution of the EFM. Additionally, crosslinking increased the stiffness of annulus fibrosus EFM.

Original languageEnglish (US)
Title of host publication2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Pages81-82
Number of pages2
DOIs
StatePublished - Jun 29 2012
Event38th Annual Northeast Bioengineering Conference, NEBEC 2012 - Philadelphia, PA, United States
Duration: Mar 16 2012Mar 18 2012

Publication series

Name2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012

Other

Other38th Annual Northeast Bioengineering Conference, NEBEC 2012
CountryUnited States
CityPhiladelphia, PA
Period3/16/123/18/12

All Science Journal Classification (ASJC) codes

  • Bioengineering

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  • Cite this

    Cortes Correales, D. H., Chiaro, J., Smith, L. J., & Elliott, D. M. (2012). Effect of crosslinking and glycosaminoglycan depletion on the extra-fibrillar matrix mechanics of annulus fibrosus. In 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012 (pp. 81-82). [6206972] (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012). https://doi.org/10.1109/NEBC.2012.6206972