Effect of crosslinking and glycosaminoglycan depletion on the extra-fibrillar matrix mechanics of annulus fibrosus

Daniel Humbe Cortes Correales; Joseph Chiaro; Lachlan J. Smith; Dawn M. Elliott

doi:10.1109/NEBC.2012.6206972

Effect of crosslinking and glycosaminoglycan depletion on the extra-fibrillar matrix mechanics of annulus fibrosus

Daniel Humbe Cortes Correales, Joseph Chiaro, Lachlan J. Smith, Dawn M. Elliott

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Protein crosslinking and glycosaminoglycan (GAG) depletion are characteristic of disc degeneration. The objective of this study is to analyze the role of these biochemical changes on the mechanics of annulus fibrosus extra-fibrillar matrix (EFM). It was found that GAG depletion decreased ionic contribution, but not the nonionic contribution of the EFM. Additionally, crosslinking increased the stiffness of annulus fibrosus EFM.

Original language	English (US)
Title of host publication	2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Pages	81-82
Number of pages	2
DOIs	https://doi.org/10.1109/NEBC.2012.6206972
State	Published - Jun 29 2012
Event	38th Annual Northeast Bioengineering Conference, NEBEC 2012 - Philadelphia, PA, United States Duration: Mar 16 2012 → Mar 18 2012

Publication series

Name	2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012

Other

Other	38th Annual Northeast Bioengineering Conference, NEBEC 2012
Country	United States
City	Philadelphia, PA
Period	3/16/12 → 3/18/12

All Science Journal Classification (ASJC) codes

Bioengineering

Access to Document

10.1109/NEBC.2012.6206972

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Cortes Correales, D. H., Chiaro, J., Smith, L. J., & Elliott, D. M. (2012). Effect of crosslinking and glycosaminoglycan depletion on the extra-fibrillar matrix mechanics of annulus fibrosus. In 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012 (pp. 81-82). [6206972] (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012). https://doi.org/10.1109/NEBC.2012.6206972

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title = "Effect of crosslinking and glycosaminoglycan depletion on the extra-fibrillar matrix mechanics of annulus fibrosus",

abstract = "Protein crosslinking and glycosaminoglycan (GAG) depletion are characteristic of disc degeneration. The objective of this study is to analyze the role of these biochemical changes on the mechanics of annulus fibrosus extra-fibrillar matrix (EFM). It was found that GAG depletion decreased ionic contribution, but not the nonionic contribution of the EFM. Additionally, crosslinking increased the stiffness of annulus fibrosus EFM.",

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Cortes Correales, DH, Chiaro, J, Smith, LJ & Elliott, DM 2012, Effect of crosslinking and glycosaminoglycan depletion on the extra-fibrillar matrix mechanics of annulus fibrosus. in 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012., 6206972, 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 81-82, 38th Annual Northeast Bioengineering Conference, NEBEC 2012, Philadelphia, PA, United States, 3/16/12. https://doi.org/10.1109/NEBC.2012.6206972

Effect of crosslinking and glycosaminoglycan depletion on the extra-fibrillar matrix mechanics of annulus fibrosus. / Cortes Correales, Daniel Humbe; Chiaro, Joseph; Smith, Lachlan J.; Elliott, Dawn M.

2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012. 2012. p. 81-82 6206972 (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - Protein crosslinking and glycosaminoglycan (GAG) depletion are characteristic of disc degeneration. The objective of this study is to analyze the role of these biochemical changes on the mechanics of annulus fibrosus extra-fibrillar matrix (EFM). It was found that GAG depletion decreased ionic contribution, but not the nonionic contribution of the EFM. Additionally, crosslinking increased the stiffness of annulus fibrosus EFM.

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Cortes Correales DH, Chiaro J, Smith LJ, Elliott DM. Effect of crosslinking and glycosaminoglycan depletion on the extra-fibrillar matrix mechanics of annulus fibrosus. In 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012. 2012. p. 81-82. 6206972. (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012). https://doi.org/10.1109/NEBC.2012.6206972