TY - GEN
T1 - Effect of crosslinking and glycosaminoglycan depletion on the extra-fibrillar matrix mechanics of annulus fibrosus
AU - Cortes Correales, Daniel Humbe
AU - Chiaro, Joseph
AU - Smith, Lachlan J.
AU - Elliott, Dawn M.
PY - 2012/6/29
Y1 - 2012/6/29
N2 - Protein crosslinking and glycosaminoglycan (GAG) depletion are characteristic of disc degeneration. The objective of this study is to analyze the role of these biochemical changes on the mechanics of annulus fibrosus extra-fibrillar matrix (EFM). It was found that GAG depletion decreased ionic contribution, but not the nonionic contribution of the EFM. Additionally, crosslinking increased the stiffness of annulus fibrosus EFM.
AB - Protein crosslinking and glycosaminoglycan (GAG) depletion are characteristic of disc degeneration. The objective of this study is to analyze the role of these biochemical changes on the mechanics of annulus fibrosus extra-fibrillar matrix (EFM). It was found that GAG depletion decreased ionic contribution, but not the nonionic contribution of the EFM. Additionally, crosslinking increased the stiffness of annulus fibrosus EFM.
UR - http://www.scopus.com/inward/record.url?scp=84862736611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862736611&partnerID=8YFLogxK
U2 - 10.1109/NEBC.2012.6206972
DO - 10.1109/NEBC.2012.6206972
M3 - Conference contribution
AN - SCOPUS:84862736611
SN - 9781467311410
T3 - 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
SP - 81
EP - 82
BT - 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
T2 - 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Y2 - 16 March 2012 through 18 March 2012
ER -