Effect of exercise on lung-perfusion scanning in patients with bronchogenic carcinoma

B. Chenuel, P. Haouzi, P. Olivier, P. Y. Marie, B. Chalon, J. Borrelly

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The aim of this study was to determine whether perfusion-scintillation scanning, used as a predictive pre-operative index of lung functionality in patients with lung cancer, is affected by the level of pulmonary blood flow (PBF). Twenty patients with primary lung cancer underwent spirometry and a radionuclide-perfusion scan (macroaggregated albumin particles labelled with 99mTechnetium) both at rest and during the last minute of a ramp-like increase in work rate until exhaustion. On average, the perfusion of the lung with the tumour was significantly reduced by the same magnitude at rest and during exercise (mean±SD: -9±6% versus -10±4% of the cardiac output), regardless of the extent of the tumour. However, subject-by-subject analysis revealed that in two patients, a larger decrease in the perfusion of the lung with the tumour was observed during exercise than at rest (-11% and -17%, respectively). This leads to an underestimation of predictive postoperative functional parameters if resting values are used in these patients. The use of perfusion scintigraphy at rest therefore gives a clear picture of the functionality of the lung before resection in most patients requiring surgery.

Original languageEnglish (US)
Pages (from-to)710-716
Number of pages7
JournalEuropean Respiratory Journal
Volume20
Issue number3
DOIs
StatePublished - Sep 2002

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

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