Effect of exercise on lung-perfusion scanning in patients with bronchogenic carcinoma

B. Chenuel, Philippe Haouzi, P. Olivier, P. Y. Marie, B. Chalon, J. Borrelly

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The aim of this study was to determine whether perfusion-scintillation scanning, used as a predictive pre-operative index of lung functionality in patients with lung cancer, is affected by the level of pulmonary blood flow (PBF). Twenty patients with primary lung cancer underwent spirometry and a radionuclide-perfusion scan (macroaggregated albumin particles labelled with 99mTechnetium) both at rest and during the last minute of a ramp-like increase in work rate until exhaustion. On average, the perfusion of the lung with the tumour was significantly reduced by the same magnitude at rest and during exercise (mean±SD: -9±6% versus -10±4% of the cardiac output), regardless of the extent of the tumour. However, subject-by-subject analysis revealed that in two patients, a larger decrease in the perfusion of the lung with the tumour was observed during exercise than at rest (-11% and -17%, respectively). This leads to an underestimation of predictive postoperative functional parameters if resting values are used in these patients. The use of perfusion scintigraphy at rest therefore gives a clear picture of the functionality of the lung before resection in most patients requiring surgery.

Original languageEnglish (US)
Pages (from-to)710-716
Number of pages7
JournalEuropean Respiratory Journal
Volume20
Issue number3
DOIs
StatePublished - Sep 1 2002

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Bronchogenic Carcinoma
Perfusion
Exercise
Lung
Lung Neoplasms
Neoplasms
Architectural Accessibility
Perfusion Imaging
Spirometry
Radioisotopes
Cardiac Output
Albumins

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Chenuel, B. ; Haouzi, Philippe ; Olivier, P. ; Marie, P. Y. ; Chalon, B. ; Borrelly, J. / Effect of exercise on lung-perfusion scanning in patients with bronchogenic carcinoma. In: European Respiratory Journal. 2002 ; Vol. 20, No. 3. pp. 710-716.
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Effect of exercise on lung-perfusion scanning in patients with bronchogenic carcinoma. / Chenuel, B.; Haouzi, Philippe; Olivier, P.; Marie, P. Y.; Chalon, B.; Borrelly, J.

In: European Respiratory Journal, Vol. 20, No. 3, 01.09.2002, p. 710-716.

Research output: Contribution to journalArticle

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