Effect of exercise on markers of inflammation in breast cancer survivors: The yale exercise and survivorship study

Sara B. Jones, Gwendolyn Thomas, Sara D. Hesselsweet, Marty Alvarez-Reeves, Herbert Yu, Melinda L. Irwin

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

Physical activity is associated with improved breast cancer survival, but the underlying mechanisms, possibly including modification of the inflammatory state, are not well understood.Weanalyzed changes in interleukin (IL)-6, C-reactive protein (CRP), and TNF-α in a randomized controlled trial of exercise in postmenopausal breast cancer survivors. Seventy-five women, recruited through the Yale-New Haven Hospital Tumor Registry, were randomized to either a six-month aerobic exercise intervention or usual care. Correlations were calculated between baseline cytokines, adiposity, and physical activity measures. Generalized linear models were used to assess the effect of exercise on IL-6, CRP, and TNF-α. At baseline, IL-6 and CRP were positively correlated with body fat and body mass index (BMI) and were inversely correlated with daily pedometer steps (P < 0.001). We found no significant effect of exercise on changes in inflammatory marker concentrations between women randomized to exercise versus usual care, though secondary analyses revealed a significant reduction in IL-6 among exercisers who reached 80% of the intervention goal compared with those who did not. Future studies should examine the effect of different types and doses of exercise and weight loss on inflammatory markers in large-scale trials of women diagnosed with breast cancer.

Original languageEnglish (US)
Pages (from-to)109-118
Number of pages10
JournalCancer Prevention Research
Volume6
Issue number2
DOIs
StatePublished - Feb 1 2013

Fingerprint

Survivors
Survival Rate
Exercise
Breast Neoplasms
Inflammation
Interleukin-6
C-Reactive Protein
Secondary Care
Fat Body
Adiposity
Registries
Adipose Tissue
Weight Loss
Linear Models
Body Mass Index
Randomized Controlled Trials
Cytokines
Survival
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Jones, Sara B. ; Thomas, Gwendolyn ; Hesselsweet, Sara D. ; Alvarez-Reeves, Marty ; Yu, Herbert ; Irwin, Melinda L. / Effect of exercise on markers of inflammation in breast cancer survivors : The yale exercise and survivorship study. In: Cancer Prevention Research. 2013 ; Vol. 6, No. 2. pp. 109-118.
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Effect of exercise on markers of inflammation in breast cancer survivors : The yale exercise and survivorship study. / Jones, Sara B.; Thomas, Gwendolyn; Hesselsweet, Sara D.; Alvarez-Reeves, Marty; Yu, Herbert; Irwin, Melinda L.

In: Cancer Prevention Research, Vol. 6, No. 2, 01.02.2013, p. 109-118.

Research output: Contribution to journalReview article

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