Effect of exposure concentration, duration, and ventilation rate on ozone absorption during continuous inhalation exposure

Marc Rigas, James S. Ultman, Abdellaziz Ben-Jebria

Research output: Contribution to journalArticle

Abstract

Ozone (O3), a component of urban smog, causes lung irritation upon inhilation and is a significant public health concern. Studies of the effect of O3 inhalation on humans typically relate exposure directly to response, with little or no consideration of the actual uptake of O3. We hypothesize that duration of exposure, inhaled concentration, and respiratory flow rate are all factors that might affect the uptake of O3 in the respiratory tract, causing a nonlinear relationship between exposure and dose. To test this hypothesis, we have designed a high-speed ozone analyzer which is capable of sampling and monitoring breath-by-breath ozone concentration in real-time in exercising individuals. We measured the fraction of inhaled O3 which was retained, Λ, in eight human subjects during continuous exposure in each of four sessions with O3 concentrations of either 0.2 or 0.4 ppm, exposure duration of 30 or 60 min., and target ventilation rates of 20 or 40 Lpm. Our results indicate that O3 uptake is proportional to ventilation rate, exposure time, and inhaled concentration such that Λ had a value of 0.86 ± 0.06 (mean ± SD) for all the subjects we tested.

Original languageEnglish (US)
Pages (from-to)2153-2156
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume5
StatePublished - Dec 1 1997

Fingerprint

Inhalation Exposure
Ozone
Ventilation
Smog
Public health
Respiratory Rate
Respiratory System
Inhalation
Public Health
Flow rate
Sampling
Lung
Monitoring

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

@article{ec290f5e9bb44b44abd148274bdd1fcb,
title = "Effect of exposure concentration, duration, and ventilation rate on ozone absorption during continuous inhalation exposure",
abstract = "Ozone (O3), a component of urban smog, causes lung irritation upon inhilation and is a significant public health concern. Studies of the effect of O3 inhalation on humans typically relate exposure directly to response, with little or no consideration of the actual uptake of O3. We hypothesize that duration of exposure, inhaled concentration, and respiratory flow rate are all factors that might affect the uptake of O3 in the respiratory tract, causing a nonlinear relationship between exposure and dose. To test this hypothesis, we have designed a high-speed ozone analyzer which is capable of sampling and monitoring breath-by-breath ozone concentration in real-time in exercising individuals. We measured the fraction of inhaled O3 which was retained, Λ, in eight human subjects during continuous exposure in each of four sessions with O3 concentrations of either 0.2 or 0.4 ppm, exposure duration of 30 or 60 min., and target ventilation rates of 20 or 40 Lpm. Our results indicate that O3 uptake is proportional to ventilation rate, exposure time, and inhaled concentration such that Λ had a value of 0.86 ± 0.06 (mean ± SD) for all the subjects we tested.",
author = "Marc Rigas and Ultman, {James S.} and Abdellaziz Ben-Jebria",
year = "1997",
month = "12",
day = "1",
language = "English (US)",
volume = "5",
pages = "2153--2156",
journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
issn = "1557-170X",
publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

Effect of exposure concentration, duration, and ventilation rate on ozone absorption during continuous inhalation exposure. / Rigas, Marc; Ultman, James S.; Ben-Jebria, Abdellaziz.

In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 5, 01.12.1997, p. 2153-2156.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of exposure concentration, duration, and ventilation rate on ozone absorption during continuous inhalation exposure

AU - Rigas, Marc

AU - Ultman, James S.

AU - Ben-Jebria, Abdellaziz

PY - 1997/12/1

Y1 - 1997/12/1

N2 - Ozone (O3), a component of urban smog, causes lung irritation upon inhilation and is a significant public health concern. Studies of the effect of O3 inhalation on humans typically relate exposure directly to response, with little or no consideration of the actual uptake of O3. We hypothesize that duration of exposure, inhaled concentration, and respiratory flow rate are all factors that might affect the uptake of O3 in the respiratory tract, causing a nonlinear relationship between exposure and dose. To test this hypothesis, we have designed a high-speed ozone analyzer which is capable of sampling and monitoring breath-by-breath ozone concentration in real-time in exercising individuals. We measured the fraction of inhaled O3 which was retained, Λ, in eight human subjects during continuous exposure in each of four sessions with O3 concentrations of either 0.2 or 0.4 ppm, exposure duration of 30 or 60 min., and target ventilation rates of 20 or 40 Lpm. Our results indicate that O3 uptake is proportional to ventilation rate, exposure time, and inhaled concentration such that Λ had a value of 0.86 ± 0.06 (mean ± SD) for all the subjects we tested.

AB - Ozone (O3), a component of urban smog, causes lung irritation upon inhilation and is a significant public health concern. Studies of the effect of O3 inhalation on humans typically relate exposure directly to response, with little or no consideration of the actual uptake of O3. We hypothesize that duration of exposure, inhaled concentration, and respiratory flow rate are all factors that might affect the uptake of O3 in the respiratory tract, causing a nonlinear relationship between exposure and dose. To test this hypothesis, we have designed a high-speed ozone analyzer which is capable of sampling and monitoring breath-by-breath ozone concentration in real-time in exercising individuals. We measured the fraction of inhaled O3 which was retained, Λ, in eight human subjects during continuous exposure in each of four sessions with O3 concentrations of either 0.2 or 0.4 ppm, exposure duration of 30 or 60 min., and target ventilation rates of 20 or 40 Lpm. Our results indicate that O3 uptake is proportional to ventilation rate, exposure time, and inhaled concentration such that Λ had a value of 0.86 ± 0.06 (mean ± SD) for all the subjects we tested.

UR - http://www.scopus.com/inward/record.url?scp=0031293269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031293269&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031293269

VL - 5

SP - 2153

EP - 2156

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

SN - 1557-170X

ER -