Effect of flavone in a canine model of myocardial stunning

S. K. Maulik, R. Kumari, M. Maulik, K. S. Reddy, S. D. Seth

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5 Scopus citations

Abstract

Putative cardioprotective action of flavone (10, 20 and 30 mg/kg) was investigated in a canine model of regional ischemia (20 min) followed by 60 min of reperfusion. In animals pretreated with vehicle, myocardial stunning was evidenced by significant changes in hemodynamic parameters (depressed mean arterial pressure, LV peak (+) dP/dt, LV peak (-) dP/dt and elevated LV end-diastolic pressure) and biochemical parameters (decreased myocardial ATP and rise in plasma malondialdehyde or MDA; a marker of free radical-induced injury). A reduction in plasma MDA was noted with 20 and 30mg/kg flayone, although attenuation of myocardial dysfunction was evident with all the three doses. The results suggest that besides a significant dose-dependent antioxidant effect, flayone may also have some cardioprotective actions per se, which needs to be further investigated.

Original languageEnglish (US)
Pages (from-to)965-970
Number of pages6
JournalIndian Journal of Experimental Biology
Volume37
Issue number10
StatePublished - Oct 1 1999

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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    Maulik, S. K., Kumari, R., Maulik, M., Reddy, K. S., & Seth, S. D. (1999). Effect of flavone in a canine model of myocardial stunning. Indian Journal of Experimental Biology, 37(10), 965-970.