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- Molecular Biology
- Cardiology and Cardiovascular Medicine
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Effect of glucocorticoids on peptide-chain initiation in heart and skeletal muscle. / Rannels, D. E.; Rannels, S. R.; Pegg, Anthony et al.In: Journal of Molecular and Cellular Cardiology, Vol. 10, No. SUPPL.1, 1978, p. 85.
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TY - JOUR
T1 - Effect of glucocorticoids on peptide-chain initiation in heart and skeletal muscle
AU - Rannels, D. E.
AU - Rannels, S. R.
AU - Pegg, Anthony
AU - Jefferson, Leonard "Jim"
N1 - Funding Information: EFFECT OF GLUCOCORTICOIDS ON PEPTIDE-CHAIN INITIATION IN HEART AND SKELETAL MUSCLE. D. E. Rannels, S. R. Rannels, A. E. Pegg and L. S. Jefferson. Dept. Physiol., Hershey Med. Cntr., Hershey, PA, U.S.A. 17033 Treatment of normal rats with cortisone acetate for 5 days reduced the rate of synthesis of skeletal muscle protein 55% as measured in the perfused rat hemicorpus. Loss of tissue RNA accounted for 15% of this decrease; the remaining reduction resulted from a block in peptide-chain initiation which developed --in vivo. Protein synthesis in perfused heart muscle was not affected by steroid treatment --in vivo, nor were tissue RNA content or peptide-chain initiation altered. Activity of an eIF-2-like initiation factor (IF) in post-ribosomal supernatants from psoas was reduced by cortisone treatment. This difference was not i lysis and was not due to accelerated rates of or to changes in nucleotide levels during incubation. activity WHS unchanged in supernatants from hearts of cortisone-treated animals. Reduced RNA content in skeletal muscle, but not in heart, of hormone-treated rats suggested a relationship between IF activity and RNA content. In other experiments, ribosomal subunits accumulated in psoas muscles of rats treated 4 hours with dexamethasone; tissue RNA content and IF activity remained unchanged. Thus, adrenocortical steroids may reduce protein synthesis in psoas, but not in heart, in part by regulating the activity of factors involved in peptide initiation; factor activity may be linked to tissue RNA content. supported by NIH grants HL20388, AM15658 and CA18138 and by The American Diabetes Association. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 1978
Y1 - 1978
UR - http://www.scopus.com/inward/record.url?scp=0018069224&partnerID=8YFLogxK
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U2 - 10.1016/0022-2828(78)90214-6
DO - 10.1016/0022-2828(78)90214-6
M3 - Article
AN - SCOPUS:0018069224
VL - 10
SP - 85
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
SN - 0022-2828
IS - SUPPL.1