Effect of healthy aging on renal vascular responses to local cooling and apnea

Hardikkumar M. Patel, Jessica L. Mast, Lawrence I. Sinoway, Matthew D. Muller

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Sympathetically mediated renal vasoconstriction may contribute to the pathogenesis of hypertension in older adults, but empirical data in support of this concept are lacking. In 10 young (26 ± 1 yr) and 11 older (67 ± 2 yr) subjects, we quantified acute hemodynamic responses to three sympathoexcitatory stimuli: local cooling of the forehead, cold pressor test (CPT), and voluntary apnea. We hypothesized that all stimuli would increase mean arterial blood pressure (MAP) and renal vascular resistance index (RVRI) and that aging would augment these effects. Beat-bybeat MAP, heart rate (HR), and renal blood flow velocity (from Doppler) were measured in the supine posture, and changes from baseline were compared between groups. In response to 1°C forehead cooling, aging was associated with an augmented MAP (20 ± 3 vs. 6 ± 2 mmHg) and RVRI (35 ± 6 vs. 16 ± 9%) but not HR. In older adults, there was a positive correlation between the cold-induced pressor response and forehead pain (R = 0.726), but this effect was not observed in young subjects. The CPT raised RVRI in both young (56 ± 13%) and older (45 ± 8%) subjects, but this was not different between groups. Relative to baseline, end-expiratory apnea increased RVRI to a similar extent in both young (46 ± 14%) and older (41 ± 9%) subjects. During sympathetic activation, renal vasoconstriction occurred in both groups. Forehead cooling caused an augmented pressor response in older adults that was related to pain perception.

Original languageEnglish (US)
Pages (from-to)90-96
Number of pages7
JournalJournal of applied physiology
Volume115
Issue number1
DOIs
StatePublished - Jul 1 2013

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Apnea
Blood Vessels
Arterial Pressure
Forehead
Kidney
Vascular Resistance
Vasoconstriction
Heart Rate
Pain Perception
Blood Flow Velocity
Renal Circulation
Posture
Hemodynamics
Hypertension
Pain

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Patel, Hardikkumar M. ; Mast, Jessica L. ; Sinoway, Lawrence I. ; Muller, Matthew D. / Effect of healthy aging on renal vascular responses to local cooling and apnea. In: Journal of applied physiology. 2013 ; Vol. 115, No. 1. pp. 90-96.
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Effect of healthy aging on renal vascular responses to local cooling and apnea. / Patel, Hardikkumar M.; Mast, Jessica L.; Sinoway, Lawrence I.; Muller, Matthew D.

In: Journal of applied physiology, Vol. 115, No. 1, 01.07.2013, p. 90-96.

Research output: Contribution to journalArticle

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