Effect of Isotretinoin on Serum Levels of Precursor and Peripherally Derived Androgens in Patients With Acne

Donald P. Lookingbill, Laurence M. Demers, Robert E. Tigelaar, Alan R. Shalita

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Abstract

Sebaceous glands are stimulated by androgens and can convert them to more active forms. Isotretinoin, however, has a profound inhibitory effect on sebaceous gland size and function. This study evaluated the effect of isotretinoin on serum levels of precursor and tissuederived androgens. Twenty-four subjects (15 men and nine women) were treated for 20 weeks with 1 mg/kg/d of isotretinoin. Serum samples were obtained at baseline, 8, 16, and 24 weeks, and assayed for precursor andro- gens—total testosterone (TT), free testosterone (free T), dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S); and tissue androgens—dihydrotestosterone (DHT), and its metabolite, 3 α-androstanediol glucuronide (3 α-diol G). Isotretinoin had no meaningful effects on precursor androgens, except for producing an elevation of free T in women. In contrast, isotretinoin produced depressions in the serum levels of DHT and 3 α-diol G in women and in 3 α-diol G in men. These decreases are believed to be the result, rather than the cause, of a reduction in the size of the sebaceous glands: The magnitude of the observed decreases may represent the amount of tissue-derived androgens that sebaceous glands normally contribute to the circulating pool.

Original languageEnglish (US)
Pages (from-to)540-543
Number of pages4
JournalArchives of dermatology
Volume124
Issue number4
DOIs
StatePublished - Apr 1988

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All Science Journal Classification (ASJC) codes

  • Dermatology

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