Effect of laparotomy on respiratory muscle activation pattern

Pritish Mondal, Mutasim Abu-Hasan, Abhishek Saha, Teresa Pitts, Melanie Rose, Donald C. Bolser, Paul W. Davenport

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Muscular tone of the abdominal wall is important in maintaining transdiaphragmatic pressures and its loss can lead to decreased lung volumes. Patients who are status postlaparotomy are at risk of developing atelectasis. The compensatory role of respiratory muscle activity in postlaparotomy is not well studied. Normally, inspiratory muscles are active during inspiration and passive during expiration to allow for lung recoil. However, electrical activities of the inspiratory muscles continue during early expiratory phase to prevent rapid loss of lung volume. This activity is known as post-inspiratory inspiratory activity (PIIA). In this study, we hypothesized that laparotomy will elicit an increase in PIIA, which is enhanced by respiratory chemical loading. Experiments were conducted in cats under three different conditions: intact abdomen (n = 3), open abdomen (n = 10), and post abdominal closure (n = 10) during eupnea and hypercapnia (10% CO2). Electromyography (EMG) activities of the diaphragm and parasternal muscles were recorded and peak EMG amplitude, PIIA time, and area under the curve were measured. Intraesophageal pressure was also obtained. PIIA was significantly higher under open abdominal conditions in comparison to intact abdomen during eupnea. Our data indicates that PIIA is increased during open abdomen and may be an important compensatory mechanism for altered respiratory mechanics induced by laparotomy. Also, PIIA remained elevated after abdominal closure. However, under hypercapnia, PIIA was significantly higher during intact abdomen in comparison to open abdomen, which is thought to be due to respiratory muscle compensation under chemical loading.

Original languageEnglish (US)
JournalPhysiological reports
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2016

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Respiratory Muscles
Abdomen
Laparotomy
Hypercapnia
Electromyography
Muscles
Lung
Respiratory Mechanics
Pressure
Pulmonary Atelectasis
Abdominal Wall
Diaphragm
Area Under Curve
Cats

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Mondal, P., Abu-Hasan, M., Saha, A., Pitts, T., Rose, M., Bolser, D. C., & Davenport, P. W. (2016). Effect of laparotomy on respiratory muscle activation pattern. Physiological reports, 4(1). https://doi.org/10.14814/phy2.12668
Mondal, Pritish ; Abu-Hasan, Mutasim ; Saha, Abhishek ; Pitts, Teresa ; Rose, Melanie ; Bolser, Donald C. ; Davenport, Paul W. / Effect of laparotomy on respiratory muscle activation pattern. In: Physiological reports. 2016 ; Vol. 4, No. 1.
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Mondal, P, Abu-Hasan, M, Saha, A, Pitts, T, Rose, M, Bolser, DC & Davenport, PW 2016, 'Effect of laparotomy on respiratory muscle activation pattern', Physiological reports, vol. 4, no. 1. https://doi.org/10.14814/phy2.12668

Effect of laparotomy on respiratory muscle activation pattern. / Mondal, Pritish; Abu-Hasan, Mutasim; Saha, Abhishek; Pitts, Teresa; Rose, Melanie; Bolser, Donald C.; Davenport, Paul W.

In: Physiological reports, Vol. 4, No. 1, 01.01.2016.

Research output: Contribution to journalArticle

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AU - Abu-Hasan, Mutasim

AU - Saha, Abhishek

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