Effect of ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in human lung cancer cell lines

Pengfei He, Michael G. Borland, Bokai Zhu, Arun Sharma, Shantu Amin, Karam El-Bayoumy, Frank J. Gonzalez, Jeffrey Maurice Peters

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

There is compelling evidence that peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) mediates terminal differentiation and is associated with inhibition of cell growth. However, it was recently suggested that growth of two human lung cancer cell lines is enhanced by PPARβ/δ. The goal of the present study was to provide insight in resolving this controversy. Therefore, the effect of ligand activation of PPARβ/δ in A549 and H1838 human lung cancer cell lines was examined using two high affinity PPARβ/δ ligands. Ligand activation of PPARβ/δ caused up-regulation of a known PPARβ/δ target gene, angiopoietin-like 4 (Angptl4) but did not influence expression of phosphatase and tensin homolog (PTEN) or phosphorylation of protein kinase B (Akt), and did not affect cell growth. Results from this study demonstrate that two human lung cancer cell lines respond to ligand activation of PPARβ/δ by modulation of target gene expression (Angptl4), but fail to exhibit significant modulation of cell proliferation.

Original languageEnglish (US)
Pages (from-to)112-117
Number of pages6
JournalToxicology
Volume254
Issue number1-2
DOIs
StatePublished - Dec 5 2008

All Science Journal Classification (ASJC) codes

  • Toxicology

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