Effect of local administration of transdermal fentanyl on peripheral opioid analgesia

Scott Worrich, Gregg Schuler, Piotr Janicki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective. Transdermal fentanyl is a commonly used analgesic for the treatment of severe chronic pain. Recent investigations have shown the presence of mu-opioid receptors in the skin and opioid analgesic efficacy with alternative routes of administration of narcotics. This placebo-controlled, double-blind prospective study assessed whether transdermal fentanyl administration produces local peripheral opioid analgesia at the site of application. Design. Baseline pain threshold and supra-threshold pain intensity assessments were measured using Quantitative Sensory Testing in 12 healthy volunteers. Placebo and fentanyl containing patches (Duragesic®, 25 μg/h) were applied to opposite forearms for 2 h. After patch removal, pain threshold, supra-threshold pain response, and the area of secondary hyperalgesia were evaluated for both forearms. Results. No statistically significant differences in pain threshold, supra-threshold pain intensity, or area of hyperalgesia in fentanyl- versus placebo-treated forearms were detected in the study subjects. Conclusion. These results suggest that the application of transdermal fentanyl patch for a period of 2 h does not produce local peripheral opioid analgesia at the site of patch application.

Original languageEnglish (US)
Pages (from-to)41-47
Number of pages7
JournalPain Medicine
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2007

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Cutaneous Administration
Fentanyl
Pain Threshold
Analgesia
Opioid Analgesics
Forearm
Hyperalgesia
Placebos
Transdermal Patch
mu Opioid Receptor
Narcotics
Pain Measurement
Double-Blind Method
Chronic Pain
Analgesics
Healthy Volunteers
Prospective Studies
Skin

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

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title = "Effect of local administration of transdermal fentanyl on peripheral opioid analgesia",
abstract = "Objective. Transdermal fentanyl is a commonly used analgesic for the treatment of severe chronic pain. Recent investigations have shown the presence of mu-opioid receptors in the skin and opioid analgesic efficacy with alternative routes of administration of narcotics. This placebo-controlled, double-blind prospective study assessed whether transdermal fentanyl administration produces local peripheral opioid analgesia at the site of application. Design. Baseline pain threshold and supra-threshold pain intensity assessments were measured using Quantitative Sensory Testing in 12 healthy volunteers. Placebo and fentanyl containing patches (Duragesic{\circledR}, 25 μg/h) were applied to opposite forearms for 2 h. After patch removal, pain threshold, supra-threshold pain response, and the area of secondary hyperalgesia were evaluated for both forearms. Results. No statistically significant differences in pain threshold, supra-threshold pain intensity, or area of hyperalgesia in fentanyl- versus placebo-treated forearms were detected in the study subjects. Conclusion. These results suggest that the application of transdermal fentanyl patch for a period of 2 h does not produce local peripheral opioid analgesia at the site of patch application.",
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Effect of local administration of transdermal fentanyl on peripheral opioid analgesia. / Worrich, Scott; Schuler, Gregg; Janicki, Piotr.

In: Pain Medicine, Vol. 8, No. 1, 01.01.2007, p. 41-47.

Research output: Contribution to journalArticle

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N2 - Objective. Transdermal fentanyl is a commonly used analgesic for the treatment of severe chronic pain. Recent investigations have shown the presence of mu-opioid receptors in the skin and opioid analgesic efficacy with alternative routes of administration of narcotics. This placebo-controlled, double-blind prospective study assessed whether transdermal fentanyl administration produces local peripheral opioid analgesia at the site of application. Design. Baseline pain threshold and supra-threshold pain intensity assessments were measured using Quantitative Sensory Testing in 12 healthy volunteers. Placebo and fentanyl containing patches (Duragesic®, 25 μg/h) were applied to opposite forearms for 2 h. After patch removal, pain threshold, supra-threshold pain response, and the area of secondary hyperalgesia were evaluated for both forearms. Results. No statistically significant differences in pain threshold, supra-threshold pain intensity, or area of hyperalgesia in fentanyl- versus placebo-treated forearms were detected in the study subjects. Conclusion. These results suggest that the application of transdermal fentanyl patch for a period of 2 h does not produce local peripheral opioid analgesia at the site of patch application.

AB - Objective. Transdermal fentanyl is a commonly used analgesic for the treatment of severe chronic pain. Recent investigations have shown the presence of mu-opioid receptors in the skin and opioid analgesic efficacy with alternative routes of administration of narcotics. This placebo-controlled, double-blind prospective study assessed whether transdermal fentanyl administration produces local peripheral opioid analgesia at the site of application. Design. Baseline pain threshold and supra-threshold pain intensity assessments were measured using Quantitative Sensory Testing in 12 healthy volunteers. Placebo and fentanyl containing patches (Duragesic®, 25 μg/h) were applied to opposite forearms for 2 h. After patch removal, pain threshold, supra-threshold pain response, and the area of secondary hyperalgesia were evaluated for both forearms. Results. No statistically significant differences in pain threshold, supra-threshold pain intensity, or area of hyperalgesia in fentanyl- versus placebo-treated forearms were detected in the study subjects. Conclusion. These results suggest that the application of transdermal fentanyl patch for a period of 2 h does not produce local peripheral opioid analgesia at the site of patch application.

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