Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer

John V. Heymach, Terry J. Shackleford, Hai T. Tran, Suk Young Yoo, Kim Anh Do, Melanie Wergin, Pierre Saintigny, Robin T. Vollmer, Thomas J. Polascik, Denise C. Snyder, Mack T. Ruffin IV, Shaoyu Yan, Mark Dewhirst, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal, Wendy Demark-Wahnefried

Research output: Contribution to journalArticle

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Abstract

Diet, nutritional status, and certain dietary supplements are postulated to influence the development and progression of prostate cancer. Angiogenesis and inflammation are central to tumor growth and progression, but the effect of diet on these processes remains uncertain. We explored changes in 50 plasma cytokines and angiogenic factors (CAF) in 145 men with prostate cancer enrolled in a preoperative, randomized controlled phase II trial with four arms: control (usual diet), low-fat (LF) diet, flaxseed-supplemented (FS) diet, and FS+LS diet. The mean duration of dietary intervention was 30 to 31 days. Among the individual arms, the largest number of significant changes (baseline vs. preoperative follow-up) was observed in the LF arm, with 19 CAFs decreasing and one increasing (P < 0.05). Compared with the control arm, 6 CAFs-including proangiogenic factors (stromal-cell derived-1α) and myeloid factors (granulocyte-colony-stimulating factor, macrophage colony-stimulating factor) - all decreased in the LF arm compared with controls; three and four CAFs changed in the FS and FS+LF arms, respectively. Weight loss occurred in the LF arms and significantly correlated with VEGF decreases (P < 0.001). The CAFs that changed in the LF arm are all known to be regulated by NF-κB, and a pathway analysis identified NF-κB as the most likely regulatory network associated with these changes in the LF arm but not in the FS-containing arms. These results suggest that a LF diet without flaxseed may reduce levels of specific inflammatory CAFs and suggests that the NF-κB pathway may be a mediator of these changes.

Original languageEnglish (US)
Pages (from-to)1590-1598
Number of pages9
JournalCancer Prevention Research
Volume4
Issue number10
DOIs
StatePublished - Oct 1 2011

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Flax
Fat-Restricted Diet
Angiogenesis Inducing Agents
Prostatic Neoplasms
Fats
Cytokines
Diet
Chemokine CXCL12
Macrophage Colony-Stimulating Factor
Granulocyte Colony-Stimulating Factor
Dietary Supplements
Nutritional Status
Vascular Endothelial Growth Factor A
Weight Loss
Inflammation
Growth
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Heymach, J. V., Shackleford, T. J., Tran, H. T., Yoo, S. Y., Do, K. A., Wergin, M., ... Demark-Wahnefried, W. (2011). Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer. Cancer Prevention Research, 4(10), 1590-1598. https://doi.org/10.1158/1940-6207.CAPR-10-0136
Heymach, John V. ; Shackleford, Terry J. ; Tran, Hai T. ; Yoo, Suk Young ; Do, Kim Anh ; Wergin, Melanie ; Saintigny, Pierre ; Vollmer, Robin T. ; Polascik, Thomas J. ; Snyder, Denise C. ; Ruffin IV, Mack T. ; Yan, Shaoyu ; Dewhirst, Mark ; Kunnumakkara, Ajaikumar B. ; Aggarwal, Bharat B. ; Demark-Wahnefried, Wendy. / Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer. In: Cancer Prevention Research. 2011 ; Vol. 4, No. 10. pp. 1590-1598.
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abstract = "Diet, nutritional status, and certain dietary supplements are postulated to influence the development and progression of prostate cancer. Angiogenesis and inflammation are central to tumor growth and progression, but the effect of diet on these processes remains uncertain. We explored changes in 50 plasma cytokines and angiogenic factors (CAF) in 145 men with prostate cancer enrolled in a preoperative, randomized controlled phase II trial with four arms: control (usual diet), low-fat (LF) diet, flaxseed-supplemented (FS) diet, and FS+LS diet. The mean duration of dietary intervention was 30 to 31 days. Among the individual arms, the largest number of significant changes (baseline vs. preoperative follow-up) was observed in the LF arm, with 19 CAFs decreasing and one increasing (P < 0.05). Compared with the control arm, 6 CAFs-including proangiogenic factors (stromal-cell derived-1α) and myeloid factors (granulocyte-colony-stimulating factor, macrophage colony-stimulating factor) - all decreased in the LF arm compared with controls; three and four CAFs changed in the FS and FS+LF arms, respectively. Weight loss occurred in the LF arms and significantly correlated with VEGF decreases (P < 0.001). The CAFs that changed in the LF arm are all known to be regulated by NF-κB, and a pathway analysis identified NF-κB as the most likely regulatory network associated with these changes in the LF arm but not in the FS-containing arms. These results suggest that a LF diet without flaxseed may reduce levels of specific inflammatory CAFs and suggests that the NF-κB pathway may be a mediator of these changes.",
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Heymach, JV, Shackleford, TJ, Tran, HT, Yoo, SY, Do, KA, Wergin, M, Saintigny, P, Vollmer, RT, Polascik, TJ, Snyder, DC, Ruffin IV, MT, Yan, S, Dewhirst, M, Kunnumakkara, AB, Aggarwal, BB & Demark-Wahnefried, W 2011, 'Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer', Cancer Prevention Research, vol. 4, no. 10, pp. 1590-1598. https://doi.org/10.1158/1940-6207.CAPR-10-0136

Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer. / Heymach, John V.; Shackleford, Terry J.; Tran, Hai T.; Yoo, Suk Young; Do, Kim Anh; Wergin, Melanie; Saintigny, Pierre; Vollmer, Robin T.; Polascik, Thomas J.; Snyder, Denise C.; Ruffin IV, Mack T.; Yan, Shaoyu; Dewhirst, Mark; Kunnumakkara, Ajaikumar B.; Aggarwal, Bharat B.; Demark-Wahnefried, Wendy.

In: Cancer Prevention Research, Vol. 4, No. 10, 01.10.2011, p. 1590-1598.

Research output: Contribution to journalArticle

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T1 - Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer

AU - Heymach, John V.

AU - Shackleford, Terry J.

AU - Tran, Hai T.

AU - Yoo, Suk Young

AU - Do, Kim Anh

AU - Wergin, Melanie

AU - Saintigny, Pierre

AU - Vollmer, Robin T.

AU - Polascik, Thomas J.

AU - Snyder, Denise C.

AU - Ruffin IV, Mack T.

AU - Yan, Shaoyu

AU - Dewhirst, Mark

AU - Kunnumakkara, Ajaikumar B.

AU - Aggarwal, Bharat B.

AU - Demark-Wahnefried, Wendy

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