Effect of medical device substrate material on nanoparticulate silver efficacy

Benita J. Dair, David M. Saylor, Kristen M. Kennedy, Rachel Casas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Silver is one of the oldest known natural antimicrobial materials, the active form being the Ag+ ion, which disrupts critical cell functions in bacteria. Reducing the size of silver particles to the nanoscale regime increases the surface area and hence the availability of silver ions, thereby enhancing their potential antimicrobial efficacy relative to their bulk counterparts. Nanoparticulate silver systems have been used as antimicrobial agents for medical device applications such as bandages, wound dressings, surgical masks, endotracheal tubes, and catheters. However the surface onto which the silver nanoparticles are deposited will impact the availability of Ag+ ions due to the chemistry of the substrate surface and its affinity for silver ions. The effect of substrate material on the efficacy of nanoparticulate silver will be discussed, along with the implications of materials selection in medical device applications.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Pages188-189
Number of pages2
Volume2
StatePublished - 2008
Event2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 - Quebec City, QC, United States
Duration: Jun 1 2008Jun 5 2008

Other

Other2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
CountryUnited States
CityQuebec City, QC
Period6/1/086/5/08

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering

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  • Cite this

    Dair, B. J., Saylor, D. M., Kennedy, K. M., & Casas, R. (2008). Effect of medical device substrate material on nanoparticulate silver efficacy. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008 (Vol. 2, pp. 188-189)