TY - JOUR
T1 - Effect of naltrexone on senile dementia of the Alzheimer type
AU - Hyman, Bradley T.
AU - Eslinger, Paul J.
AU - Damasio, Antonio R.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - Some reports have suggested that naloxone, a short-acting opiate receptor blocker given intravenously, has a beneficial effect on the symptoms of senile dementia of the Alzheimier type. We have performed a double-blind, crossover trial of naltrexone, an orally active, long acting opiate antagonist, in 17 Alzheimer-type dementia patients. None showed any improvement in assessments of day-to-day living skills or on a battery of neuropsychological tests. No side effects were noted. In the dosage used, naltrexone appears not to be useful in Alzheimer-type dementia.
AB - Some reports have suggested that naloxone, a short-acting opiate receptor blocker given intravenously, has a beneficial effect on the symptoms of senile dementia of the Alzheimier type. We have performed a double-blind, crossover trial of naltrexone, an orally active, long acting opiate antagonist, in 17 Alzheimer-type dementia patients. None showed any improvement in assessments of day-to-day living skills or on a battery of neuropsychological tests. No side effects were noted. In the dosage used, naltrexone appears not to be useful in Alzheimer-type dementia.
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U2 - 10.1136/jnnp.48.11.1169
DO - 10.1136/jnnp.48.11.1169
M3 - Article
C2 - 3001233
AN - SCOPUS:0022398152
VL - 48
SP - 1169
EP - 1171
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 11
ER -