Effect of preeclampsia on mortality, intraventricular hemorrhage, and need for mechanical ventilation in very low-birth-weight infants

David A. Paul, June Kepler, Kathleen H. Leef, Anthony Siscione, Charles Palmer, John L. Stefano

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Infants born to mothers with preeclampsia have been shown to have a reduction in intraventricular hemorrhage (IVH). The objective of this article is to investigate the relationship between preeclampsia, IVH, neonatal mortality, mechanical ventilation; and other potential confounding variables such as neutropenia and magnesium sulfate. Methods of research include review of infants <1500 g admitted to a single level III neonatal intensive care unit (NICU), n = 356. Infants born to mothers with preeclampsia were compared to those without maternal preeclampsia by univariate and multivariate analysis. Overall, 52 mothers were diagnosed with preeclampsia. After multivariate modeling, preeclampsia was not associated with a decrease in mechanical ventilation (odds ratio 0.5, 95% CI 0.2-1.3), IVH (odds ratio 0.5, 0.1-1.9) or mortality (odds ratio 0.6, 0.2-1.9). In our population, after controlling for multiple confounding variables, including MgSO4, neutropenia and thrombocytopenia, there was no difference in the odds of mortality, IVH, or requirement for mechanical ventilation in infants born to mothers with preeclampsia as compared to infants born to mothers without preeclampsia.

Original languageEnglish (US)
Pages (from-to)381-386
Number of pages6
JournalAmerican Journal of Perinatology
Volume15
Issue number6
DOIs
StatePublished - Jan 1 1998

Fingerprint

Very Low Birth Weight Infant
Pre-Eclampsia
Artificial Respiration
Hemorrhage
Mortality
Mothers
Confounding Factors (Epidemiology)
Odds Ratio
Neutropenia
Magnesium Sulfate
Neonatal Intensive Care Units
Infant Mortality
Thrombocytopenia
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Paul, David A. ; Kepler, June ; Leef, Kathleen H. ; Siscione, Anthony ; Palmer, Charles ; Stefano, John L. / Effect of preeclampsia on mortality, intraventricular hemorrhage, and need for mechanical ventilation in very low-birth-weight infants. In: American Journal of Perinatology. 1998 ; Vol. 15, No. 6. pp. 381-386.
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Effect of preeclampsia on mortality, intraventricular hemorrhage, and need for mechanical ventilation in very low-birth-weight infants. / Paul, David A.; Kepler, June; Leef, Kathleen H.; Siscione, Anthony; Palmer, Charles; Stefano, John L.

In: American Journal of Perinatology, Vol. 15, No. 6, 01.01.1998, p. 381-386.

Research output: Contribution to journalArticle

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