Effect of presurgical aerobic exercise on cardiometabolic health 30 days after bariatric surgery

Nicole M. Gilbertson, Natalie Z.M. Eichner, Julian M. Gaitán, Mahnoor Khurshid, Elizabeth A. Rexrode, Sibylle Kranz, Peter T. Hallowell, Steven K. Malin

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the effect of preoperative standard medical care (SC) vs. unsupervised aerobic exercise combined with SC (EX + SC) on cardiometabolic health and quality of life (QoL) 30 days after bariatric surgery. Bariatric patients (n = 14, age: 42.3 ± 2.5 years, body mass index: 45.1 ± 2.5 kg/m2) were match-paired to presurgical SC (n = 7) or EX + SC (n = 7; walking 30 min/day, 5 day/week, 65–85% HRpeak) for 30 days. Body composition, peak cardiorespiratory fitness (VO2peak), QoL, inflammation (adiponectin, leptin, cytokeratin-18), and a 120 min mixed meal tolerance test was performed to assess aortic waveforms (augmentation index, AIx@75), insulin sensitivity, and glucose total area under the curve (tAUC) at the time of surgery (post-intervention) and 30 days post-surgery. EX + SC had significantly higher high molecular weight (HMW) adiponectin (p = 0.01) and ratio of HMW to total adiponectin (p = 0.04) than SC at 30 days post-surgery, although they significantly (p = 0.006; ES = 1.86) decreased total time spent in moderate to vigorous physical activity (MVPA). SC had a significantly greater increase in VO2peak (p = 0.02; ES = 1.54) and decrease in 120 min AIx@75 (p = 0.02; ES = 1.78) than EX + SC during the post-surgical period. The increase in MVPA was associated with a reduction in cytokeratin-18 (r = −0.67, p = 0.02). Increased VO2peak was associated with increased activity/mobility QoL domain (r = 0.52, p = 0.05) and decreased 120 min AIx@75 (r = −0.61, p = 0.03) from surgery to post-surgery. Preoperative EX + SC did not maintain more favorable cardiometabolic health 30 days post-operation in this pilot study. However, changes in MVPA appear important for QoL and should be considered in future work.

Original languageEnglish (US)
Article numbere15039
JournalPhysiological reports
Volume9
Issue number21
DOIs
StatePublished - Nov 2021

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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