Effect of probenecid on the kinetics of epsilon‐aminocaproic acid

Barry H. Dvorchik, Kerry L. Katlic, Arthur H. Hayes, M. Elaine Eyster

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Healthy male subjects received, 1 wk apart, single oral doses of epsilon‐aminocaproic acid (EACA) 100 mg/kg alone, EACA with probenecid (0.5 gm), or EACA 2 hr after 2.0 gm probenecid. Probenecid (2.0 gm) reduced the 8‐hr urinary clearance and recovery of EACA by 50% without affecting plasma kinetics. Recovery of EACA in urine rose to 78% of the dose 48 hr after EACA. Plasma clearance of EACA did not differ from control EACA urinary clearance when 0.5 gm probenecid was given with EACA. In both cases all the EACA dose was recovered in urine within 8 hr. Clinical Pharmacology and Therapeutics (1980) 28, 223–228; doi:

    Original languageEnglish (US)
    Pages (from-to)223-228
    Number of pages6
    JournalClinical Pharmacology & Therapeutics
    Volume28
    Issue number2
    DOIs
    StatePublished - Aug 1980

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    Probenecid
    Acids
    Urine
    Clinical Pharmacology
    Healthy Volunteers

    All Science Journal Classification (ASJC) codes

    • Pharmacology
    • Pharmacology (medical)

    Cite this

    Dvorchik, Barry H. ; Katlic, Kerry L. ; Hayes, Arthur H. ; Eyster, M. Elaine. / Effect of probenecid on the kinetics of epsilon‐aminocaproic acid. In: Clinical Pharmacology & Therapeutics. 1980 ; Vol. 28, No. 2. pp. 223-228.
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    abstract = "Healthy male subjects received, 1 wk apart, single oral doses of epsilon‐aminocaproic acid (EACA) 100 mg/kg alone, EACA with probenecid (0.5 gm), or EACA 2 hr after 2.0 gm probenecid. Probenecid (2.0 gm) reduced the 8‐hr urinary clearance and recovery of EACA by 50{\%} without affecting plasma kinetics. Recovery of EACA in urine rose to 78{\%} of the dose 48 hr after EACA. Plasma clearance of EACA did not differ from control EACA urinary clearance when 0.5 gm probenecid was given with EACA. In both cases all the EACA dose was recovered in urine within 8 hr. Clinical Pharmacology and Therapeutics (1980) 28, 223–228; doi:",
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    Effect of probenecid on the kinetics of epsilon‐aminocaproic acid. / Dvorchik, Barry H.; Katlic, Kerry L.; Hayes, Arthur H.; Eyster, M. Elaine.

    In: Clinical Pharmacology & Therapeutics, Vol. 28, No. 2, 08.1980, p. 223-228.

    Research output: Contribution to journalArticle

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    AU - Dvorchik, Barry H.

    AU - Katlic, Kerry L.

    AU - Hayes, Arthur H.

    AU - Eyster, M. Elaine

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    AB - Healthy male subjects received, 1 wk apart, single oral doses of epsilon‐aminocaproic acid (EACA) 100 mg/kg alone, EACA with probenecid (0.5 gm), or EACA 2 hr after 2.0 gm probenecid. Probenecid (2.0 gm) reduced the 8‐hr urinary clearance and recovery of EACA by 50% without affecting plasma kinetics. Recovery of EACA in urine rose to 78% of the dose 48 hr after EACA. Plasma clearance of EACA did not differ from control EACA urinary clearance when 0.5 gm probenecid was given with EACA. In both cases all the EACA dose was recovered in urine within 8 hr. Clinical Pharmacology and Therapeutics (1980) 28, 223–228; doi:

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