Effect of pulsatile or continuous administration of pituitary-derived chicken growth hormone (p-cGH) on lipid metabolism in broiler pullets

R. W. Rosebrough, J. P. McMurtry, R. Vasilatos-Younken

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

1. 1. The effects of pulsatile and continuous intravenous administration of exogenous, pituitary-derived chicken growth hormone (p-cGH) on lipid metabolism and endocrine/metabolite levels of broiler-strain pullets were studied. 2. 2. Eight-week-old pullets were administered p-cGH or vehicle over a 10 min period every 90 min for 7 days. 3. 3. Pullets were also administered the same daily amount (123 μg/kg of body weight/day) continuously for 7 days. 4. 4. Feed intake, body weight gain, in vitro lipogenesis and hepatic enzyme activities were determined with certain hormones identified with the control of growth. 5. 5. Pulsatile p-cGH administration for 7 days lacked effect on weight gain, feed efficiency, muscle or bone development. 6. 6. Abdominal fat pad size was decreased (P < 0.05) by pulsatile but not continuous administration of p-cGH. Pulsatile p-cGH administration also decreased (P < 0.05) in vitro lipogenesis. Liver malic enzyme and isocitrate dehydrogenase activities were increased (P < 0.05) by pulsatile but not continuous administration of p-cGH. In contrast, glutamic oxaloacetic transaminase activity was increased by a continuous infusion of p-cGH. 7. 7. Plasma concentrations of T4 corticosterone and triglycerides were decreased (P < 0.05) by a pulsatile but not a constant infusion of p-cGH. 8. 8. Plasma T3 and GH were increased (P < 0.05) by pulsatile p-cGH compared to both a continuous infusion of p-cGH and the saline controls. 9. 9. This study is the first to prove that in the broiler chicken, the pattern of exogenous p-cGH administration is a factor influencing in vitro responses to the hormone.

Original languageEnglish (US)
Pages (from-to)207-214
Number of pages8
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume99
Issue number1-2
DOIs
StatePublished - 1991

All Science Journal Classification (ASJC) codes

  • Physiology

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