Effect of side group chemistry on the properties of biodegradable l-alanine cosubstituted polyphosphazenes

Anurima Singh, Nicholas R. Krogman, Swaminathan Sethuraman, Lakshmi S. Nair, Jaqueline L. Sturgeon, Paul W. Brown, Cato T. Laurencin, Harry R. Allcock

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Biodegradable polyphosphazenes have been investigated for a variety of applications, such as controlled drug delivery matrixes, tissue-engineering scaffolds, membranes, and bone-type composites. In this study we have evaluated the effect of side group chemistry on the properties of biodegradable phosphazene polymers that contain ethyl alanato side groups together with ethyl glycinato, p-methylphenoxy, or p-phenylphenoxy side groups. The polymers were synthesized by a macromolecular substitution route. The molecular weights of aryloxy/amino acid ester cosubstituted polymers were much higher than the amino acid ester substituted polyphosphazenes described earlier. Polymer properties, such as glass transition temperature, hydrolytic degradation, surface wettability, tensile strength, and modulus of elasticity varied over a wide range following changes to the type of co-substituents on the polymer backbone. The glass transition temperatures varied from -10 to 35 °C and increased with the bulkiness of the side groups. Polymer films in phosphate buffer saline solution showed molecular weight declines ranging from 58% to >80% and mass loss ranging from 4% to 90% over a period of 7 weeks. Water contact angles for polymer films varied from 63° to 107°, with the highest angles for the alanine ethyl ester and p-phenylphenoxy cosubstituted polyphosphazene. The tensile strengths were in the range of 2.4-7.6 MPa and the modulus of elasticity was in the range of 31.4-455.9 MPa. Thus, in this study we have demonstrated the tunability of biodegradable polyphosphazenes to suit a range of biomedical applications.

Original languageEnglish (US)
Pages (from-to)914-918
Number of pages5
JournalBiomacromolecules
Volume7
Issue number3
DOIs
StatePublished - Mar 1 2006

Fingerprint

Alanine
Polymers
Esters
Elastic moduli
Polymer films
Amino acids
Tensile strength
Molecular weight
Controlled drug delivery
Tissue Scaffolds
Amino Acids
Biodegradable polymers
Scaffolds (biology)
Tissue engineering
Sodium Chloride
Contact angle
Wetting
Buffers
Bone
Phosphates

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Singh, Anurima ; Krogman, Nicholas R. ; Sethuraman, Swaminathan ; Nair, Lakshmi S. ; Sturgeon, Jaqueline L. ; Brown, Paul W. ; Laurencin, Cato T. ; Allcock, Harry R. / Effect of side group chemistry on the properties of biodegradable l-alanine cosubstituted polyphosphazenes. In: Biomacromolecules. 2006 ; Vol. 7, No. 3. pp. 914-918.
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Singh, A, Krogman, NR, Sethuraman, S, Nair, LS, Sturgeon, JL, Brown, PW, Laurencin, CT & Allcock, HR 2006, 'Effect of side group chemistry on the properties of biodegradable l-alanine cosubstituted polyphosphazenes', Biomacromolecules, vol. 7, no. 3, pp. 914-918. https://doi.org/10.1021/bm050752r

Effect of side group chemistry on the properties of biodegradable l-alanine cosubstituted polyphosphazenes. / Singh, Anurima; Krogman, Nicholas R.; Sethuraman, Swaminathan; Nair, Lakshmi S.; Sturgeon, Jaqueline L.; Brown, Paul W.; Laurencin, Cato T.; Allcock, Harry R.

In: Biomacromolecules, Vol. 7, No. 3, 01.03.2006, p. 914-918.

Research output: Contribution to journalArticle

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AU - Singh, Anurima

AU - Krogman, Nicholas R.

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