Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits

L. B. Wilson, C. K. Dyke, D. Parsons, P. T. Wall, James Anthony Pawelczyk, R. S. Williams, J. H. Mitchell

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The purpose of this study was to determine whether the reflex hemodynamic responses to static contraction of predominately glycolytic muscle are greater than the changes elicited by primarily oxidative muscle. Low- frequency electrical stimulation (continuous 21 days) of the tibial nerve of one hindlimb of adult rabbits converted the metabolic characteristics of the predominately glycolytic gastrocnemius to a muscle that was primarily oxidative. After 21 days of stimulation, the rabbits were decerebrated, and static contraction of the glycolytic muscle (unstimulated gastrocnemius) initially decreased heart rate (HR; -16 ± 3 beats/min) and mean arterial pressure (MAP; -17 ± 3 mmHg). Thereafter, MAP increased 13 ± 3 mmHg above baseline. Static contraction of the oxidative muscle (stimulated gastrocnemius/produced similar decreases in HR and MAP (-12 ± 4 beat/min and -12 ± 3 mmHg, respectively). However, the subsequent increase in MAP (8 ± 3 mmHg; above baseline) was less than that evoked by contraction of the glycolytic muscle. The responses evoked by stretch of each muscle and high- intensity electrical stimulation were the same, indicating that the afferents from the muscle were not destroyed by the chronic-stimulation technique. These results support the hypothesis that metabolic by-products play a role in the pressor response to static contraction of skeletal muscle. In addition, these data confirm that contraction of predominately oxidative muscle can evoke a reflex presser response, albeit smaller than the change elicited from primarily glycolytic muscle.

Original languageEnglish (US)
Pages (from-to)1744-1752
Number of pages9
JournalJournal of Applied Physiology
Volume79
Issue number5
DOIs
StatePublished - Jan 1 1995

Fingerprint

Skeletal Muscle Fibers
Rabbits
Muscles
Muscle Contraction
Skeletal Muscle
Electric Stimulation
Reflex
Tibial Nerve
Hindlimb
Arterial Pressure
Heart Rate
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Wilson, L. B. ; Dyke, C. K. ; Parsons, D. ; Wall, P. T. ; Pawelczyk, James Anthony ; Williams, R. S. ; Mitchell, J. H. / Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits. In: Journal of Applied Physiology. 1995 ; Vol. 79, No. 5. pp. 1744-1752.
@article{df2923b4c00e4c868542d8c23763514b,
title = "Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits",
abstract = "The purpose of this study was to determine whether the reflex hemodynamic responses to static contraction of predominately glycolytic muscle are greater than the changes elicited by primarily oxidative muscle. Low- frequency electrical stimulation (continuous 21 days) of the tibial nerve of one hindlimb of adult rabbits converted the metabolic characteristics of the predominately glycolytic gastrocnemius to a muscle that was primarily oxidative. After 21 days of stimulation, the rabbits were decerebrated, and static contraction of the glycolytic muscle (unstimulated gastrocnemius) initially decreased heart rate (HR; -16 ± 3 beats/min) and mean arterial pressure (MAP; -17 ± 3 mmHg). Thereafter, MAP increased 13 ± 3 mmHg above baseline. Static contraction of the oxidative muscle (stimulated gastrocnemius/produced similar decreases in HR and MAP (-12 ± 4 beat/min and -12 ± 3 mmHg, respectively). However, the subsequent increase in MAP (8 ± 3 mmHg; above baseline) was less than that evoked by contraction of the glycolytic muscle. The responses evoked by stretch of each muscle and high- intensity electrical stimulation were the same, indicating that the afferents from the muscle were not destroyed by the chronic-stimulation technique. These results support the hypothesis that metabolic by-products play a role in the pressor response to static contraction of skeletal muscle. In addition, these data confirm that contraction of predominately oxidative muscle can evoke a reflex presser response, albeit smaller than the change elicited from primarily glycolytic muscle.",
author = "Wilson, {L. B.} and Dyke, {C. K.} and D. Parsons and Wall, {P. T.} and Pawelczyk, {James Anthony} and Williams, {R. S.} and Mitchell, {J. H.}",
year = "1995",
month = "1",
day = "1",
doi = "10.1152/jappl.1995.79.5.1744",
language = "English (US)",
volume = "79",
pages = "1744--1752",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "5",

}

Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits. / Wilson, L. B.; Dyke, C. K.; Parsons, D.; Wall, P. T.; Pawelczyk, James Anthony; Williams, R. S.; Mitchell, J. H.

In: Journal of Applied Physiology, Vol. 79, No. 5, 01.01.1995, p. 1744-1752.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits

AU - Wilson, L. B.

AU - Dyke, C. K.

AU - Parsons, D.

AU - Wall, P. T.

AU - Pawelczyk, James Anthony

AU - Williams, R. S.

AU - Mitchell, J. H.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - The purpose of this study was to determine whether the reflex hemodynamic responses to static contraction of predominately glycolytic muscle are greater than the changes elicited by primarily oxidative muscle. Low- frequency electrical stimulation (continuous 21 days) of the tibial nerve of one hindlimb of adult rabbits converted the metabolic characteristics of the predominately glycolytic gastrocnemius to a muscle that was primarily oxidative. After 21 days of stimulation, the rabbits were decerebrated, and static contraction of the glycolytic muscle (unstimulated gastrocnemius) initially decreased heart rate (HR; -16 ± 3 beats/min) and mean arterial pressure (MAP; -17 ± 3 mmHg). Thereafter, MAP increased 13 ± 3 mmHg above baseline. Static contraction of the oxidative muscle (stimulated gastrocnemius/produced similar decreases in HR and MAP (-12 ± 4 beat/min and -12 ± 3 mmHg, respectively). However, the subsequent increase in MAP (8 ± 3 mmHg; above baseline) was less than that evoked by contraction of the glycolytic muscle. The responses evoked by stretch of each muscle and high- intensity electrical stimulation were the same, indicating that the afferents from the muscle were not destroyed by the chronic-stimulation technique. These results support the hypothesis that metabolic by-products play a role in the pressor response to static contraction of skeletal muscle. In addition, these data confirm that contraction of predominately oxidative muscle can evoke a reflex presser response, albeit smaller than the change elicited from primarily glycolytic muscle.

AB - The purpose of this study was to determine whether the reflex hemodynamic responses to static contraction of predominately glycolytic muscle are greater than the changes elicited by primarily oxidative muscle. Low- frequency electrical stimulation (continuous 21 days) of the tibial nerve of one hindlimb of adult rabbits converted the metabolic characteristics of the predominately glycolytic gastrocnemius to a muscle that was primarily oxidative. After 21 days of stimulation, the rabbits were decerebrated, and static contraction of the glycolytic muscle (unstimulated gastrocnemius) initially decreased heart rate (HR; -16 ± 3 beats/min) and mean arterial pressure (MAP; -17 ± 3 mmHg). Thereafter, MAP increased 13 ± 3 mmHg above baseline. Static contraction of the oxidative muscle (stimulated gastrocnemius/produced similar decreases in HR and MAP (-12 ± 4 beat/min and -12 ± 3 mmHg, respectively). However, the subsequent increase in MAP (8 ± 3 mmHg; above baseline) was less than that evoked by contraction of the glycolytic muscle. The responses evoked by stretch of each muscle and high- intensity electrical stimulation were the same, indicating that the afferents from the muscle were not destroyed by the chronic-stimulation technique. These results support the hypothesis that metabolic by-products play a role in the pressor response to static contraction of skeletal muscle. In addition, these data confirm that contraction of predominately oxidative muscle can evoke a reflex presser response, albeit smaller than the change elicited from primarily glycolytic muscle.

UR - http://www.scopus.com/inward/record.url?scp=0028783731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028783731&partnerID=8YFLogxK

U2 - 10.1152/jappl.1995.79.5.1744

DO - 10.1152/jappl.1995.79.5.1744

M3 - Article

C2 - 8594037

AN - SCOPUS:0028783731

VL - 79

SP - 1744

EP - 1752

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 5

ER -