Effect of Smoking and Alcohol Consumption on Laryngeal Cancer Risk in Coastal Texas

Roni T. Falk, Linda Williams Pickle, Linda Morris Brown, Thomas J. Mason, Patricia A. Buffler, Joseph F. Fraumeni

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Data from case-control studies of respiratory cancer conducted in the Texas Gulf Coast region between 1975 and 1980 were used to examine the effects of smoking and alcohol on laryngeal cancer risk. Analyses were limited to living white males, aged 30-79, which included 151 histologically confirmed incident laryngeal cancer cases and 235 population-based controls. A dose-dependent effect for cigarette smoking was observed, with odds ratios ranging from 4.4 for ever smoking up to one-half pack daily, to 10.4 for smoking more than two packs per day. Risks were strongest for current smokers and declined markedly following smoking cessation. Higher risks were associated with smoking nonfiltered than filtered cigarettes. No significantly elevated risks were associated with the use of other tobacco products. Odds ratios for alcoholic beverages did not increase linearly with increasing use; instead risks were twofold for consumption of four or more drinks weekly. Patterns of risk associated with beer and hard liquor were not consistent and few participants drank wine. Although the data were sparse, a dose-response effect for alcohol intake was suggested for tumors of the supraglottis (n = 23), while for nonsupraglottic cases, alcohol risks were elevated but did not Increase beyond those observed for four drinks per week. Predicted risks for the combined effects of cigarette and alcohol use were intermediate between an additive and multiplicative form of interaction.

Original languageEnglish (US)
Pages (from-to)4024-4029
Number of pages6
JournalCancer Research
Volume49
Issue number14
StatePublished - Jul 15 1989

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Laryngeal Neoplasms
Alcohol Drinking
Smoking
Alcohols
Tobacco Products
Odds Ratio
Alcoholic Beverages
Population Control
Smoking Cessation
Wine
Case-Control Studies
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Falk, R. T., Pickle, L. W., Brown, L. M., Mason, T. J., Buffler, P. A., & Fraumeni, J. F. (1989). Effect of Smoking and Alcohol Consumption on Laryngeal Cancer Risk in Coastal Texas. Cancer Research, 49(14), 4024-4029.
Falk, Roni T. ; Pickle, Linda Williams ; Brown, Linda Morris ; Mason, Thomas J. ; Buffler, Patricia A. ; Fraumeni, Joseph F. / Effect of Smoking and Alcohol Consumption on Laryngeal Cancer Risk in Coastal Texas. In: Cancer Research. 1989 ; Vol. 49, No. 14. pp. 4024-4029.
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Falk, RT, Pickle, LW, Brown, LM, Mason, TJ, Buffler, PA & Fraumeni, JF 1989, 'Effect of Smoking and Alcohol Consumption on Laryngeal Cancer Risk in Coastal Texas', Cancer Research, vol. 49, no. 14, pp. 4024-4029.

Effect of Smoking and Alcohol Consumption on Laryngeal Cancer Risk in Coastal Texas. / Falk, Roni T.; Pickle, Linda Williams; Brown, Linda Morris; Mason, Thomas J.; Buffler, Patricia A.; Fraumeni, Joseph F.

In: Cancer Research, Vol. 49, No. 14, 15.07.1989, p. 4024-4029.

Research output: Contribution to journalArticle

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Falk RT, Pickle LW, Brown LM, Mason TJ, Buffler PA, Fraumeni JF. Effect of Smoking and Alcohol Consumption on Laryngeal Cancer Risk in Coastal Texas. Cancer Research. 1989 Jul 15;49(14):4024-4029.