Effect of spacer arm length on the performance of charge-modified ultrafiltration membranes

Amit Mehta, Andrew Zydney

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

A series of novel charged ultrafiltration membranes that differed in spacer arm length and charge group functionality was developed using epichlorohydrin (EPI) activation of a commercially available regenerated cellulose membrane. Hydraulic permeability and protein retention data were obtained over a range of ionic strength using cytochrome c as a model protein. Membrane properties were also examined using dextran sieving, streaming potential, and counter-electro-osmosis measurements. The results clearly demonstrate that considerable improvements in membrane performance can be achieved by proper design of the membrane charge functionality, and in particular the spacer arm length, providing new opportunities for optimization of ultrafiltration membranes for bioprocessing applications.

Original languageEnglish (US)
Pages (from-to)304-314
Number of pages11
JournalJournal of Membrane Science
Volume313
Issue number1-2
DOIs
StatePublished - Apr 10 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Materials Science(all)
  • Physical and Theoretical Chemistry
  • Filtration and Separation

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