Effect of team sport participation on genetic predisposition to adolescent smoking progression

Janet Audrain-McGovern, Daniel Rodriguez, E. Paul Wileyto, Kathryn H. Schmitz, Peter G. Shields

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Context: There is much to be learned about why some adolescents progress to a regular smoking habit and others do not. Objective: To evaluate whether (1) team sport participation buffers the effect of having 2 smoking risk genotypes (the dopamine reuptake transporter [SLC6A3] and the dopamine D2 receptor [DRD2]) or 1 of these risk genotypes vs having none on adolescent smoking progression and (2) the buffering effects of team sports were due to physical activity associated with team sport participation. Design: Longitudinal cohort study. Survey data were collected annually from grade 9 to the end of grade 12. Self-report measures included smoking, team sport participation, physical activity, depression, smoking exposure, and alcohol and marijuana use. DNA was collected via buccal swabs. Data were analyzed using latent growth modeling. Setting: Five public high schools in Virginia. Participants:Atotal of 361 students of European ancestry. Main Outcome Measure: Smoking progression. Results: For adolescents participating in at least 1 team sport, but not for adolescents with no team sport participation, physical activity had a significant negative effect on smoking progression (z = -3.85, P < .001; χ1,N=3612 = 6.73, P = .009). In addition, having 1 (z = 2.69; P = .007) and 2 (z = 2.22; P = .03) smoking risk genotypes had a positive effect on physical activity. These represented significant between-group effects (χ1,N=3612 = 6.29, P = .01; χ1,N=3612 = 3.81, P = .05, respectively). Thus, having 1 or more smoking risk genotypes was related to higher levels of physical activity, which, in turn, was related to lower levels of smoking progression for adolescents participating in at least 1 team sport but not for adolescents with no team sport participation. Conclusions: This study provides the first evidence of an interaction between environmental influences and specific genes on adolescent smoking and may promote an understanding of important protective relationships in the environment.

Original languageEnglish (US)
Pages (from-to)433-441
Number of pages9
JournalArchives of General Psychiatry
Volume63
Issue number4
DOIs
StatePublished - Apr 1 2006

Fingerprint

Genetic Predisposition to Disease
Sports
Smoking
Exercise
Genotype
Participation
Predisposition
Progression
Dopamine Plasma Membrane Transport Proteins
Dopamine D2 Receptors
Cheek
Cannabis
Self Report
Habits
Longitudinal Studies
Buffers
Cohort Studies
Alcohols
Outcome Assessment (Health Care)
Physical Activity

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Audrain-McGovern, Janet ; Rodriguez, Daniel ; Wileyto, E. Paul ; Schmitz, Kathryn H. ; Shields, Peter G. / Effect of team sport participation on genetic predisposition to adolescent smoking progression. In: Archives of General Psychiatry. 2006 ; Vol. 63, No. 4. pp. 433-441.
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Effect of team sport participation on genetic predisposition to adolescent smoking progression. / Audrain-McGovern, Janet; Rodriguez, Daniel; Wileyto, E. Paul; Schmitz, Kathryn H.; Shields, Peter G.

In: Archives of General Psychiatry, Vol. 63, No. 4, 01.04.2006, p. 433-441.

Research output: Contribution to journalArticle

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