Effect of the antihypertensive drug hydralazine on mineral metabolism in the rat

Jeffrey Maurice Peters, Bo Lönnerdal, Carl L. Keen

Research output: Contribution to journalArticle

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Abstract

The effects of hydralazine (HZ) on mineral metabolism was investigated in rats. Sprague-Dawley rats were fed HZ (0.1-4%, w/w) in three separate experiments: (1) a 2-week dose-response study; (2) a 2-month long-term feeding study; and (3) a pregnancy study. At the end of each experiment, tissues were removed and concentrations of Mn, Cu, Zn and Fe were measured. Results from the three experiments were similar. HZ had no effect on tissue Mn and Zn concentrations, while tissue Fe concentrations were lower and kidney Cu concentrations were higher in HZ-treated groups compared to controls. The effect of HZ on mineral metabolism may be, in part, responsible for some of its negative side effects.

Original languageEnglish (US)
Pages (from-to)193-202
Number of pages10
JournalToxicology Letters
Volume41
Issue number3
DOIs
StatePublished - Jan 1 1988

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Hydralazine
Metabolism
Antihypertensive Agents
Minerals
Rats
Tissue
Experiments
Sprague Dawley Rats
Kidney
Pregnancy

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

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abstract = "The effects of hydralazine (HZ) on mineral metabolism was investigated in rats. Sprague-Dawley rats were fed HZ (0.1-4{\%}, w/w) in three separate experiments: (1) a 2-week dose-response study; (2) a 2-month long-term feeding study; and (3) a pregnancy study. At the end of each experiment, tissues were removed and concentrations of Mn, Cu, Zn and Fe were measured. Results from the three experiments were similar. HZ had no effect on tissue Mn and Zn concentrations, while tissue Fe concentrations were lower and kidney Cu concentrations were higher in HZ-treated groups compared to controls. The effect of HZ on mineral metabolism may be, in part, responsible for some of its negative side effects.",
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Effect of the antihypertensive drug hydralazine on mineral metabolism in the rat. / Peters, Jeffrey Maurice; Lönnerdal, Bo; Keen, Carl L.

In: Toxicology Letters, Vol. 41, No. 3, 01.01.1988, p. 193-202.

Research output: Contribution to journalArticle

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