Effect of the stress phase angle on the strain energy density of the endothelial plasma membrane

Shigeru Tada, Cheng Dong, John M. Tarbell

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Endothelial cells are simultaneously exposed to the mechanical forces of fluid wall shear stress (WSS) imposed by blood flow and solid circumferential stress (CS) induced by the blood vessel's elastic response to the pressure pulse. Experiments have demonstrated that these combined forces induce unique endothelial biomolecular responses that are not characteristic of either driving force alone and that the temporal phase angle between WSS and CS, referred to as the stress phase angle, modulates endothelial responses. In this article, we provide the first theoretical model to examine the combined forces of WSS and CS on a model of the endothelial cell plasma membrane. We focus on the strain energy density of the membrane that modulates the opening of ion channels that can mediate signal transduction. The model shows a significant influence of the stress phase angle on the strain energy density at the upstream and downstream ends of the cell where mechanotransduction is most likely to occur.

Original languageEnglish (US)
Pages (from-to)3026-3033
Number of pages8
JournalBiophysical Journal
Volume93
Issue number9
DOIs
StatePublished - Jan 1 2007

Fingerprint

Endothelial Cells
Cell Membrane
Ion Channels
Blood Vessels
Signal Transduction
Theoretical Models
Blood Pressure
Membranes

All Science Journal Classification (ASJC) codes

  • Biophysics

Cite this

@article{e612da72b3fa4b4bb00a427ae28c1ccb,
title = "Effect of the stress phase angle on the strain energy density of the endothelial plasma membrane",
abstract = "Endothelial cells are simultaneously exposed to the mechanical forces of fluid wall shear stress (WSS) imposed by blood flow and solid circumferential stress (CS) induced by the blood vessel's elastic response to the pressure pulse. Experiments have demonstrated that these combined forces induce unique endothelial biomolecular responses that are not characteristic of either driving force alone and that the temporal phase angle between WSS and CS, referred to as the stress phase angle, modulates endothelial responses. In this article, we provide the first theoretical model to examine the combined forces of WSS and CS on a model of the endothelial cell plasma membrane. We focus on the strain energy density of the membrane that modulates the opening of ion channels that can mediate signal transduction. The model shows a significant influence of the stress phase angle on the strain energy density at the upstream and downstream ends of the cell where mechanotransduction is most likely to occur.",
author = "Shigeru Tada and Cheng Dong and Tarbell, {John M.}",
year = "2007",
month = "1",
day = "1",
doi = "10.1529/biophysj.106.100685",
language = "English (US)",
volume = "93",
pages = "3026--3033",
journal = "Biophysical Journal",
issn = "0006-3495",
publisher = "Biophysical Society",
number = "9",

}

Effect of the stress phase angle on the strain energy density of the endothelial plasma membrane. / Tada, Shigeru; Dong, Cheng; Tarbell, John M.

In: Biophysical Journal, Vol. 93, No. 9, 01.01.2007, p. 3026-3033.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of the stress phase angle on the strain energy density of the endothelial plasma membrane

AU - Tada, Shigeru

AU - Dong, Cheng

AU - Tarbell, John M.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Endothelial cells are simultaneously exposed to the mechanical forces of fluid wall shear stress (WSS) imposed by blood flow and solid circumferential stress (CS) induced by the blood vessel's elastic response to the pressure pulse. Experiments have demonstrated that these combined forces induce unique endothelial biomolecular responses that are not characteristic of either driving force alone and that the temporal phase angle between WSS and CS, referred to as the stress phase angle, modulates endothelial responses. In this article, we provide the first theoretical model to examine the combined forces of WSS and CS on a model of the endothelial cell plasma membrane. We focus on the strain energy density of the membrane that modulates the opening of ion channels that can mediate signal transduction. The model shows a significant influence of the stress phase angle on the strain energy density at the upstream and downstream ends of the cell where mechanotransduction is most likely to occur.

AB - Endothelial cells are simultaneously exposed to the mechanical forces of fluid wall shear stress (WSS) imposed by blood flow and solid circumferential stress (CS) induced by the blood vessel's elastic response to the pressure pulse. Experiments have demonstrated that these combined forces induce unique endothelial biomolecular responses that are not characteristic of either driving force alone and that the temporal phase angle between WSS and CS, referred to as the stress phase angle, modulates endothelial responses. In this article, we provide the first theoretical model to examine the combined forces of WSS and CS on a model of the endothelial cell plasma membrane. We focus on the strain energy density of the membrane that modulates the opening of ion channels that can mediate signal transduction. The model shows a significant influence of the stress phase angle on the strain energy density at the upstream and downstream ends of the cell where mechanotransduction is most likely to occur.

UR - http://www.scopus.com/inward/record.url?scp=36048994096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36048994096&partnerID=8YFLogxK

U2 - 10.1529/biophysj.106.100685

DO - 10.1529/biophysj.106.100685

M3 - Article

C2 - 17660317

AN - SCOPUS:36048994096

VL - 93

SP - 3026

EP - 3033

JO - Biophysical Journal

JF - Biophysical Journal

SN - 0006-3495

IS - 9

ER -