Effect of the stress phase angle on the strain energy density of the endothelial plasma membrane

Shigeru Tada, Cheng Dong, John M. Tarbell

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Endothelial cells are simultaneously exposed to the mechanical forces of fluid wall shear stress (WSS) imposed by blood flow and solid circumferential stress (CS) induced by the blood vessel's elastic response to the pressure pulse. Experiments have demonstrated that these combined forces induce unique endothelial biomolecular responses that are not characteristic of either driving force alone and that the temporal phase angle between WSS and CS, referred to as the stress phase angle, modulates endothelial responses. In this article, we provide the first theoretical model to examine the combined forces of WSS and CS on a model of the endothelial cell plasma membrane. We focus on the strain energy density of the membrane that modulates the opening of ion channels that can mediate signal transduction. The model shows a significant influence of the stress phase angle on the strain energy density at the upstream and downstream ends of the cell where mechanotransduction is most likely to occur.

Original languageEnglish (US)
Pages (from-to)3026-3033
Number of pages8
JournalBiophysical journal
Volume93
Issue number9
DOIs
StatePublished - Nov 2007

All Science Journal Classification (ASJC) codes

  • Biophysics

Fingerprint Dive into the research topics of 'Effect of the stress phase angle on the strain energy density of the endothelial plasma membrane'. Together they form a unique fingerprint.

  • Cite this