Effect of trace mineral supplementation on selected minerals, energy metabolites, oxidative stress, and immune parameters and its association with uterine diseases in dairy cattle

M. L.S. Bicalho, F. S. Lima, Erika Ganda, C. Foditsch, E. B.S. Meira, V. S. Machado, A. G.V. Teixeira, G. Oikonomou, R. O. Gilbert, R. C. Bicalho

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The objective of this study was to evaluate the relationship between selected minerals' serum levels, energy metabolites, oxidative stress indicators, IL-8 and haptoglobin levels, and the potential for uterine diseases. Additionally, we investigated the effect of injectable trace mineral supplementation (ITMS) on metabolism, immune function, and animal health under field conditions involving a dairy herd with high milk production. The study was conducted in 1 dairy farm located near Ithaca, New York, with 270 multiparous cows were enrolled from October 3, 2012 until January 10, 2013. Cows were randomly allocated into 1 of 2 treatments groups: ITMS or control. Cows randomly assigned to the ITMS group received 2 injections of trace minerals at 230 and 260 d of gestation; each injection contained 300. mg of Zn, 50. mg of Mn, 25. mg of Se, and 75. mg of Cu. Retained placenta (RP) and metritis were diagnosed and treated by trained farm personnel. Clinical endometritis evaluation was performed by the investigators. Blood mineral levels, plasma nonesterified fatty acids and serum β-hydroxybutyrate concentrations, plasma IL-8 concentrations, serum haptoglobin concentration, and serum superoxidase dismutase and plasma glutathione peroxidase activities were measured at various time points before and after calving. Four groups of mixed general linear models were fitted to the data using MIXED procedure of SAS. Injectable trace mineral-supplemented cows had increased serum concentration of Cu, Se, and Zn. Conversely, ITMS did not affect energy metabolites or immune and oxidative stress parameters. Serum concentration of Ca, Cu, K, Mg, Mo, Ps, Pt, Se, and Zn varied according to days relative to parturition. Cows with RP had reduced serum concentrations of Ca, Mg, Mo, and Zn when compared with cows without RP. Cows affected with metritis had significantly lower serum concentrations of Ca, Mo, soluble P, total P, Se, and Zn than nonaffected cows. Serum concentration of Ca, Cu, Mo, and Zn were reduced in cows diagnosed with endometritis in comparison to nonaffected ones.

Original languageEnglish (US)
Pages (from-to)4281-4295
Number of pages15
JournalJournal of dairy science
Volume97
Issue number7
DOIs
StatePublished - Jan 1 2014

Fingerprint

uterine diseases
Uterine Diseases
Trace Elements
blood serum
dairy cattle
Minerals
trace elements
Oxidative Stress
oxidative stress
metabolites
minerals
cows
energy
Serum
endometritis
Retained Placenta
Injections
retained placenta
Endometritis
Haptoglobins

All Science Journal Classification (ASJC) codes

  • Food Science
  • Animal Science and Zoology
  • Genetics

Cite this

Bicalho, M. L.S. ; Lima, F. S. ; Ganda, Erika ; Foditsch, C. ; Meira, E. B.S. ; Machado, V. S. ; Teixeira, A. G.V. ; Oikonomou, G. ; Gilbert, R. O. ; Bicalho, R. C. / Effect of trace mineral supplementation on selected minerals, energy metabolites, oxidative stress, and immune parameters and its association with uterine diseases in dairy cattle. In: Journal of dairy science. 2014 ; Vol. 97, No. 7. pp. 4281-4295.
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Effect of trace mineral supplementation on selected minerals, energy metabolites, oxidative stress, and immune parameters and its association with uterine diseases in dairy cattle. / Bicalho, M. L.S.; Lima, F. S.; Ganda, Erika; Foditsch, C.; Meira, E. B.S.; Machado, V. S.; Teixeira, A. G.V.; Oikonomou, G.; Gilbert, R. O.; Bicalho, R. C.

In: Journal of dairy science, Vol. 97, No. 7, 01.01.2014, p. 4281-4295.

Research output: Contribution to journalArticle

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