Effect of transient reduction of cerebral blood flow in normotensive rats on striatal dopamine-release

S. Läer, F. Block, G. Huether, C. Heim, K. H. Sontag

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Bilateral Clamping of both Carotid Arteries (BCCA) in normotensive rats is known to cause a transient reduction in cerebral blood flow. Using in vivo transstriatal microdialysis and HPLC/ECD we measured the release of dopamine and DA-metabolites under these oligemic conditions. BCCA caused a substantial stimulation of striatal DA-release (40-fold) and a decrease of the outflow of DA-metabolites. The elevated DA-release returned to baseline levels before the onset of reperfusion. Upon reperfusion, DA-metabolites rose above their initial baseline values. Transstriatal administration of glutamatediethylester (GDEE, 10 mM) attenuated the oligemia-induced DA-release. A sudden reduction of blood flow appears to disrupt the compartmentation of dopamine in striatal dopaminergic nerve endings in a similar but more moderate manner as compared to ischemia.

Original languageEnglish (US)
Pages (from-to)203-211
Number of pages9
JournalJournal of Neural Transmission
Volume92
Issue number2-3
DOIs
StatePublished - Jun 1993

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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