Effect of vitamin e on the immune response of channel catfish to edwardsiella ictaluri

David J. Wise, J. R. Tomasso, Thomas E. Schwedler, V. S. Blazer, D. M. Gatlin

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Three-month-old fingerling channel catfish Ictalurus punctatus were fed purified diets supplemented with a-tocopherol acetate to provide 0, 60, and 2, 500 mg vitamin E/kg for 180 d. A 30-s immersion bath and an oral booster were used to deliver a bacterin of formalin-killed Edwardsiella ictaluri to half of the fish from each dietary treatment. Resistance of red blood cells to peroxidation was used as an index of antioxidant status. The susceptibility of red blood cells to oxidative hemolysis decreased with increasing levels of dietary vitamin E. Vaccinated and nonvaccinated fish were evaluated for agglutinating antibody titers and macrophage activity. Humoral antibody titers in response to E. ictaluri were significantly (P < 0.05) higher in vaccinated fish than in nonvaccinated fish; however, no such differences in agglutinating antibody titers were detected among any of the dietary treatment groups. Both vaccination and vitamin E significantly enhanced the ability of macrophages to phagocytize virulent E. ictaluri. Results of this study indicate that elevated levels of dietary vitamin E may affect the ability of channel catfish to respond immunologically to bacterial pathogens.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalJournal of Aquatic Animal Health
Volume5
Issue number3
DOIs
StatePublished - Sep 1993

All Science Journal Classification (ASJC) codes

  • Aquatic Science

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