TY - JOUR
T1 - Effect of Weight Loss on Menstrual Function in Adolescents with Polycystic Ovary Syndrome
AU - Ornstein, Rollyn M.
AU - Copperman, Nancy M.
AU - Jacobson, Marc S.
N1 - Funding Information:
Supported by Long Island Jewish Medical Center Small Grants.
PY - 2011/6
Y1 - 2011/6
N2 - Study Objective: To compare the effects of a hypocaloric low-fat diet with those of a very low carbohydrate diet on body mass index (BMI), waist circumference (WC), and menstrual function in overweight adolescent females with polycystic ovary syndrome (PCOS). Design: Randomized pilot trial of two diets in a prospective, 12-week study. Setting: A hospital-based, academic adolescent medicine division. Participants: 24 females, age 12-22 years (mean 15.8 ± 2.2), with PCOS and a BMI above the 85th percentile for age (mean 35.7 ± 6.0 kg/m2). Interventions: Nutrition counseling was given biweekly, and dietary compliance, menstrual history, and weight were recorded. WC was measured at the beginning and end of the study. Main Outcome Measures: Changes in weight, BMI, WC, and improvement in menstrual function over the course of the study period. Results: 16 participants completed the study. 12 completers menstruated during the study period, 8 with regularity. The number of periods over 3 months increased from 0.6 ± 0.6 pre-treatment to 1.6 ± 1.3 post-treatment (P = 0.003). Overall, weight loss averaged 6.5% (P < 0.0001) and the WC decreased by an average of 5.7 ± 7.7 cm (P = 0.01). Those who lost weight were 3.4 times more likely to have improved menstrual function (P = 0.001). There were no statistically significant differences between the two groups. Conclusions: Weight loss is feasible in adolescents with PCOS and results in significant improvements in BMI, WC, and menstrual function. Weight management may be preferable as first-line treatment in adolescents, because it targets both the menstrual dysfunction and risk factors for long-term morbidity associated with PCOS.
AB - Study Objective: To compare the effects of a hypocaloric low-fat diet with those of a very low carbohydrate diet on body mass index (BMI), waist circumference (WC), and menstrual function in overweight adolescent females with polycystic ovary syndrome (PCOS). Design: Randomized pilot trial of two diets in a prospective, 12-week study. Setting: A hospital-based, academic adolescent medicine division. Participants: 24 females, age 12-22 years (mean 15.8 ± 2.2), with PCOS and a BMI above the 85th percentile for age (mean 35.7 ± 6.0 kg/m2). Interventions: Nutrition counseling was given biweekly, and dietary compliance, menstrual history, and weight were recorded. WC was measured at the beginning and end of the study. Main Outcome Measures: Changes in weight, BMI, WC, and improvement in menstrual function over the course of the study period. Results: 16 participants completed the study. 12 completers menstruated during the study period, 8 with regularity. The number of periods over 3 months increased from 0.6 ± 0.6 pre-treatment to 1.6 ± 1.3 post-treatment (P = 0.003). Overall, weight loss averaged 6.5% (P < 0.0001) and the WC decreased by an average of 5.7 ± 7.7 cm (P = 0.01). Those who lost weight were 3.4 times more likely to have improved menstrual function (P = 0.001). There were no statistically significant differences between the two groups. Conclusions: Weight loss is feasible in adolescents with PCOS and results in significant improvements in BMI, WC, and menstrual function. Weight management may be preferable as first-line treatment in adolescents, because it targets both the menstrual dysfunction and risk factors for long-term morbidity associated with PCOS.
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U2 - 10.1016/j.jpag.2011.01.002
DO - 10.1016/j.jpag.2011.01.002
M3 - Article
C2 - 21419674
AN - SCOPUS:79956148250
VL - 24
SP - 161
EP - 165
JO - Journal of Pediatric and Adolescent Gynecology
JF - Journal of Pediatric and Adolescent Gynecology
SN - 1083-3188
IS - 3
ER -