Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder: Based on parental report

Christine M. Pennesi, Laura Cousino Klein

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Objectives: Studies on the gluten-free and/or casein-free (GFCF) dietary intervention for children with autism spectrum disorders (ASDs) suggest that some children may positively respond to implementation of the dietary intervention. Other research suggests that children diagnosed with ASD can be classified into subpopulations based on various factors, including gastrointestinal (GI) abnormalities and immune function. Methods: This study analyzes parental report data collected using a 90-item online questionnaire from 387 parents or primary caregivers of children diagnosed with ASD on the efficacy of the GFCF diet. Parents reported on their child's GI symptoms, food allergy diagnoses, and suspected food sensitivities, as well as the degree and length of their diet implementation. Results: Overall, diet efficacy among children whose parents reported the presence of GI symptoms, food allergy diagnoses, and suspected food sensitivities included greater improvement in ASD behaviors, physiological symptoms, and social behaviors compared with children whose parents reported none of these symptoms, diagnoses, or sensitivities (P < 0.05). Parental report of strict diet implementation, indicated by complete gluten/casein elimination and infrequent diet errors during and outside of parental care, also corresponded to improvement in ASD behaviors, physiological symptoms, and social behaviors (P < 0.05). Discussion: These findings suggest that various intricacies related to diet implementation and GI and immune factors may play a role in differentiating diet responders from diet non-responders and substantiate the importance of further investigations into the various, nuanced factors that influence efficacy of the intervention among children with ASDs.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalNutritional Neuroscience
Volume15
Issue number2
DOIs
StatePublished - Mar 1 2012

Fingerprint

Glutens
Caseins
Diet
Parents
Food Hypersensitivity
Social Behavior
Food
Autism Spectrum Disorder
Immunologic Factors
Caregivers
Research

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

Cite this

@article{911a116b489142c4aaf7020d362f4a4c,
title = "Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder: Based on parental report",
abstract = "Objectives: Studies on the gluten-free and/or casein-free (GFCF) dietary intervention for children with autism spectrum disorders (ASDs) suggest that some children may positively respond to implementation of the dietary intervention. Other research suggests that children diagnosed with ASD can be classified into subpopulations based on various factors, including gastrointestinal (GI) abnormalities and immune function. Methods: This study analyzes parental report data collected using a 90-item online questionnaire from 387 parents or primary caregivers of children diagnosed with ASD on the efficacy of the GFCF diet. Parents reported on their child's GI symptoms, food allergy diagnoses, and suspected food sensitivities, as well as the degree and length of their diet implementation. Results: Overall, diet efficacy among children whose parents reported the presence of GI symptoms, food allergy diagnoses, and suspected food sensitivities included greater improvement in ASD behaviors, physiological symptoms, and social behaviors compared with children whose parents reported none of these symptoms, diagnoses, or sensitivities (P < 0.05). Parental report of strict diet implementation, indicated by complete gluten/casein elimination and infrequent diet errors during and outside of parental care, also corresponded to improvement in ASD behaviors, physiological symptoms, and social behaviors (P < 0.05). Discussion: These findings suggest that various intricacies related to diet implementation and GI and immune factors may play a role in differentiating diet responders from diet non-responders and substantiate the importance of further investigations into the various, nuanced factors that influence efficacy of the intervention among children with ASDs.",
author = "Pennesi, {Christine M.} and Klein, {Laura Cousino}",
year = "2012",
month = "3",
day = "1",
doi = "10.1179/1476830512Y.0000000003",
language = "English (US)",
volume = "15",
pages = "85--91",
journal = "Nutritional Neuroscience",
issn = "1028-415X",
publisher = "Maney Publishing",
number = "2",

}

Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder : Based on parental report. / Pennesi, Christine M.; Klein, Laura Cousino.

In: Nutritional Neuroscience, Vol. 15, No. 2, 01.03.2012, p. 85-91.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder

T2 - Based on parental report

AU - Pennesi, Christine M.

AU - Klein, Laura Cousino

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Objectives: Studies on the gluten-free and/or casein-free (GFCF) dietary intervention for children with autism spectrum disorders (ASDs) suggest that some children may positively respond to implementation of the dietary intervention. Other research suggests that children diagnosed with ASD can be classified into subpopulations based on various factors, including gastrointestinal (GI) abnormalities and immune function. Methods: This study analyzes parental report data collected using a 90-item online questionnaire from 387 parents or primary caregivers of children diagnosed with ASD on the efficacy of the GFCF diet. Parents reported on their child's GI symptoms, food allergy diagnoses, and suspected food sensitivities, as well as the degree and length of their diet implementation. Results: Overall, diet efficacy among children whose parents reported the presence of GI symptoms, food allergy diagnoses, and suspected food sensitivities included greater improvement in ASD behaviors, physiological symptoms, and social behaviors compared with children whose parents reported none of these symptoms, diagnoses, or sensitivities (P < 0.05). Parental report of strict diet implementation, indicated by complete gluten/casein elimination and infrequent diet errors during and outside of parental care, also corresponded to improvement in ASD behaviors, physiological symptoms, and social behaviors (P < 0.05). Discussion: These findings suggest that various intricacies related to diet implementation and GI and immune factors may play a role in differentiating diet responders from diet non-responders and substantiate the importance of further investigations into the various, nuanced factors that influence efficacy of the intervention among children with ASDs.

AB - Objectives: Studies on the gluten-free and/or casein-free (GFCF) dietary intervention for children with autism spectrum disorders (ASDs) suggest that some children may positively respond to implementation of the dietary intervention. Other research suggests that children diagnosed with ASD can be classified into subpopulations based on various factors, including gastrointestinal (GI) abnormalities and immune function. Methods: This study analyzes parental report data collected using a 90-item online questionnaire from 387 parents or primary caregivers of children diagnosed with ASD on the efficacy of the GFCF diet. Parents reported on their child's GI symptoms, food allergy diagnoses, and suspected food sensitivities, as well as the degree and length of their diet implementation. Results: Overall, diet efficacy among children whose parents reported the presence of GI symptoms, food allergy diagnoses, and suspected food sensitivities included greater improvement in ASD behaviors, physiological symptoms, and social behaviors compared with children whose parents reported none of these symptoms, diagnoses, or sensitivities (P < 0.05). Parental report of strict diet implementation, indicated by complete gluten/casein elimination and infrequent diet errors during and outside of parental care, also corresponded to improvement in ASD behaviors, physiological symptoms, and social behaviors (P < 0.05). Discussion: These findings suggest that various intricacies related to diet implementation and GI and immune factors may play a role in differentiating diet responders from diet non-responders and substantiate the importance of further investigations into the various, nuanced factors that influence efficacy of the intervention among children with ASDs.

UR - http://www.scopus.com/inward/record.url?scp=84858767189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858767189&partnerID=8YFLogxK

U2 - 10.1179/1476830512Y.0000000003

DO - 10.1179/1476830512Y.0000000003

M3 - Article

C2 - 22564339

AN - SCOPUS:84858767189

VL - 15

SP - 85

EP - 91

JO - Nutritional Neuroscience

JF - Nutritional Neuroscience

SN - 1028-415X

IS - 2

ER -