Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer

A meta-analysis of individual patient data

Maike G. Sweegers, Teatske M. Altenburg, Johannes Brug, Anne M. May, Jonna K. Van Vulpen, Neil K. Aaronson, Gill Arbane, Martin Bohus, Kerry S. Courneya, Amanda J. Daley, Daniel A. Galvao, Rachel Garrod, Kathleen A. Griffith, Wim H. Van Harten, Sandra C. Hayes, Fernando Herrero-Román, Marie J. Kersten, Alejandro Lucia, Alex McConnachie, Willem Van Mechelen & 19 others Nanette Mutrie, Robert U. Newton, Frans Nollet, Karin Potthoff, Martina E. Schmidt, Kathryn Schmitz, Karl Heinz Schulz, Gabe Sonke, Karen Steindorf, Martijn M. Stuiver, Dennis R. Taaffe, Lene Thorsen, Jos W. Twisk, Miranda J. Velthuis, Jennifer Wenzel, Kerri M. Winters-Stone, Joachim Wiskemann, Mai J.Chin A. Paw, Laurien M. Buffart

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Objective To optimally target exercise interventions for patients with cancer, it is important to identify which patients benefit from which interventions. Design We conducted an individual patient data meta-analysis to investigate demographic, clinical, intervention-related and exercise-related moderators of exercise intervention effects on physical fitness in patients with cancer. Data sources We identified relevant studies via systematic searches in electronic databases (PubMed, Embase, PsycINFO and CINAHL). Eligibility criteria We analysed data from 28 randomised controlled trials investigating the effects of exercise on upper body muscle strength (UBMS) and lower body muscle strength (LBMS), lower body muscle function (LBMF) and aerobic fitness in adult patients with cancer. Results Exercise significantly improved UBMS (β=0.20, 95% Confidence Interval (CI) 0.14 to 0.26), LBMS (β=0.29, 95% CI 0.23 to 0.35), LBMF (β=0.16, 95% CI 0.08 to 0.24) and aerobic fitness (β=0.28, 95% CI 0.23 to 0.34), with larger effects for supervised interventions. Exercise effects on UBMS were larger during treatment, when supervised interventions included ≥3 sessions per week, when resistance exercises were included and when session duration was >60 min. Exercise effects on LBMS were larger for patients who were living alone, for supervised interventions including resistance exercise and when session duration was >60 min. Exercise effects on aerobic fitness were larger for younger patients and when supervised interventions included aerobic exercise. Conclusion Exercise interventions during and following cancer treatment had small effects on UBMS, LBMS, LBMF and aerobic fitness. Demographic, intervention-related and exercise-related characteristics including age, marital status, intervention timing, delivery mode and frequency and type and time of exercise sessions moderated the exercise effect on UBMS, LBMS and aerobic fitness.

Original languageEnglish (US)
Number of pages1
JournalBritish journal of sports medicine
Volume53
Issue number13
DOIs
StatePublished - Jul 1 2019

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Muscle Strength
Meta-Analysis
Exercise
Muscles
Neoplasms
Confidence Intervals
Demography
Physical Fitness
Information Storage and Retrieval
Marital Status
PubMed

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Sweegers, Maike G. ; Altenburg, Teatske M. ; Brug, Johannes ; May, Anne M. ; Van Vulpen, Jonna K. ; Aaronson, Neil K. ; Arbane, Gill ; Bohus, Martin ; Courneya, Kerry S. ; Daley, Amanda J. ; Galvao, Daniel A. ; Garrod, Rachel ; Griffith, Kathleen A. ; Van Harten, Wim H. ; Hayes, Sandra C. ; Herrero-Román, Fernando ; Kersten, Marie J. ; Lucia, Alejandro ; McConnachie, Alex ; Van Mechelen, Willem ; Mutrie, Nanette ; Newton, Robert U. ; Nollet, Frans ; Potthoff, Karin ; Schmidt, Martina E. ; Schmitz, Kathryn ; Schulz, Karl Heinz ; Sonke, Gabe ; Steindorf, Karen ; Stuiver, Martijn M. ; Taaffe, Dennis R. ; Thorsen, Lene ; Twisk, Jos W. ; Velthuis, Miranda J. ; Wenzel, Jennifer ; Winters-Stone, Kerri M. ; Wiskemann, Joachim ; Paw, Mai J.Chin A. ; Buffart, Laurien M. / Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer : A meta-analysis of individual patient data. In: British journal of sports medicine. 2019 ; Vol. 53, No. 13.
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title = "Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer: A meta-analysis of individual patient data",
abstract = "Objective To optimally target exercise interventions for patients with cancer, it is important to identify which patients benefit from which interventions. Design We conducted an individual patient data meta-analysis to investigate demographic, clinical, intervention-related and exercise-related moderators of exercise intervention effects on physical fitness in patients with cancer. Data sources We identified relevant studies via systematic searches in electronic databases (PubMed, Embase, PsycINFO and CINAHL). Eligibility criteria We analysed data from 28 randomised controlled trials investigating the effects of exercise on upper body muscle strength (UBMS) and lower body muscle strength (LBMS), lower body muscle function (LBMF) and aerobic fitness in adult patients with cancer. Results Exercise significantly improved UBMS (β=0.20, 95{\%} Confidence Interval (CI) 0.14 to 0.26), LBMS (β=0.29, 95{\%} CI 0.23 to 0.35), LBMF (β=0.16, 95{\%} CI 0.08 to 0.24) and aerobic fitness (β=0.28, 95{\%} CI 0.23 to 0.34), with larger effects for supervised interventions. Exercise effects on UBMS were larger during treatment, when supervised interventions included ≥3 sessions per week, when resistance exercises were included and when session duration was >60 min. Exercise effects on LBMS were larger for patients who were living alone, for supervised interventions including resistance exercise and when session duration was >60 min. Exercise effects on aerobic fitness were larger for younger patients and when supervised interventions included aerobic exercise. Conclusion Exercise interventions during and following cancer treatment had small effects on UBMS, LBMS, LBMF and aerobic fitness. Demographic, intervention-related and exercise-related characteristics including age, marital status, intervention timing, delivery mode and frequency and type and time of exercise sessions moderated the exercise effect on UBMS, LBMS and aerobic fitness.",
author = "Sweegers, {Maike G.} and Altenburg, {Teatske M.} and Johannes Brug and May, {Anne M.} and {Van Vulpen}, {Jonna K.} and Aaronson, {Neil K.} and Gill Arbane and Martin Bohus and Courneya, {Kerry S.} and Daley, {Amanda J.} and Galvao, {Daniel A.} and Rachel Garrod and Griffith, {Kathleen A.} and {Van Harten}, {Wim H.} and Hayes, {Sandra C.} and Fernando Herrero-Rom{\'a}n and Kersten, {Marie J.} and Alejandro Lucia and Alex McConnachie and {Van Mechelen}, Willem and Nanette Mutrie and Newton, {Robert U.} and Frans Nollet and Karin Potthoff and Schmidt, {Martina E.} and Kathryn Schmitz and Schulz, {Karl Heinz} and Gabe Sonke and Karen Steindorf and Stuiver, {Martijn M.} and Taaffe, {Dennis R.} and Lene Thorsen and Twisk, {Jos W.} and Velthuis, {Miranda J.} and Jennifer Wenzel and Winters-Stone, {Kerri M.} and Joachim Wiskemann and Paw, {Mai J.Chin A.} and Buffart, {Laurien M.}",
year = "2019",
month = "7",
day = "1",
doi = "10.1136/bjsports-2018-099191",
language = "English (US)",
volume = "53",
journal = "British Journal of Sports Medicine",
issn = "0306-3674",
publisher = "BMJ Publishing Group",
number = "13",

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Sweegers, MG, Altenburg, TM, Brug, J, May, AM, Van Vulpen, JK, Aaronson, NK, Arbane, G, Bohus, M, Courneya, KS, Daley, AJ, Galvao, DA, Garrod, R, Griffith, KA, Van Harten, WH, Hayes, SC, Herrero-Román, F, Kersten, MJ, Lucia, A, McConnachie, A, Van Mechelen, W, Mutrie, N, Newton, RU, Nollet, F, Potthoff, K, Schmidt, ME, Schmitz, K, Schulz, KH, Sonke, G, Steindorf, K, Stuiver, MM, Taaffe, DR, Thorsen, L, Twisk, JW, Velthuis, MJ, Wenzel, J, Winters-Stone, KM, Wiskemann, J, Paw, MJCA & Buffart, LM 2019, 'Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer: A meta-analysis of individual patient data', British journal of sports medicine, vol. 53, no. 13. https://doi.org/10.1136/bjsports-2018-099191

Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer : A meta-analysis of individual patient data. / Sweegers, Maike G.; Altenburg, Teatske M.; Brug, Johannes; May, Anne M.; Van Vulpen, Jonna K.; Aaronson, Neil K.; Arbane, Gill; Bohus, Martin; Courneya, Kerry S.; Daley, Amanda J.; Galvao, Daniel A.; Garrod, Rachel; Griffith, Kathleen A.; Van Harten, Wim H.; Hayes, Sandra C.; Herrero-Román, Fernando; Kersten, Marie J.; Lucia, Alejandro; McConnachie, Alex; Van Mechelen, Willem; Mutrie, Nanette; Newton, Robert U.; Nollet, Frans; Potthoff, Karin; Schmidt, Martina E.; Schmitz, Kathryn; Schulz, Karl Heinz; Sonke, Gabe; Steindorf, Karen; Stuiver, Martijn M.; Taaffe, Dennis R.; Thorsen, Lene; Twisk, Jos W.; Velthuis, Miranda J.; Wenzel, Jennifer; Winters-Stone, Kerri M.; Wiskemann, Joachim; Paw, Mai J.Chin A.; Buffart, Laurien M.

In: British journal of sports medicine, Vol. 53, No. 13, 01.07.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer

T2 - A meta-analysis of individual patient data

AU - Sweegers, Maike G.

AU - Altenburg, Teatske M.

AU - Brug, Johannes

AU - May, Anne M.

AU - Van Vulpen, Jonna K.

AU - Aaronson, Neil K.

AU - Arbane, Gill

AU - Bohus, Martin

AU - Courneya, Kerry S.

AU - Daley, Amanda J.

AU - Galvao, Daniel A.

AU - Garrod, Rachel

AU - Griffith, Kathleen A.

AU - Van Harten, Wim H.

AU - Hayes, Sandra C.

AU - Herrero-Román, Fernando

AU - Kersten, Marie J.

AU - Lucia, Alejandro

AU - McConnachie, Alex

AU - Van Mechelen, Willem

AU - Mutrie, Nanette

AU - Newton, Robert U.

AU - Nollet, Frans

AU - Potthoff, Karin

AU - Schmidt, Martina E.

AU - Schmitz, Kathryn

AU - Schulz, Karl Heinz

AU - Sonke, Gabe

AU - Steindorf, Karen

AU - Stuiver, Martijn M.

AU - Taaffe, Dennis R.

AU - Thorsen, Lene

AU - Twisk, Jos W.

AU - Velthuis, Miranda J.

AU - Wenzel, Jennifer

AU - Winters-Stone, Kerri M.

AU - Wiskemann, Joachim

AU - Paw, Mai J.Chin A.

AU - Buffart, Laurien M.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Objective To optimally target exercise interventions for patients with cancer, it is important to identify which patients benefit from which interventions. Design We conducted an individual patient data meta-analysis to investigate demographic, clinical, intervention-related and exercise-related moderators of exercise intervention effects on physical fitness in patients with cancer. Data sources We identified relevant studies via systematic searches in electronic databases (PubMed, Embase, PsycINFO and CINAHL). Eligibility criteria We analysed data from 28 randomised controlled trials investigating the effects of exercise on upper body muscle strength (UBMS) and lower body muscle strength (LBMS), lower body muscle function (LBMF) and aerobic fitness in adult patients with cancer. Results Exercise significantly improved UBMS (β=0.20, 95% Confidence Interval (CI) 0.14 to 0.26), LBMS (β=0.29, 95% CI 0.23 to 0.35), LBMF (β=0.16, 95% CI 0.08 to 0.24) and aerobic fitness (β=0.28, 95% CI 0.23 to 0.34), with larger effects for supervised interventions. Exercise effects on UBMS were larger during treatment, when supervised interventions included ≥3 sessions per week, when resistance exercises were included and when session duration was >60 min. Exercise effects on LBMS were larger for patients who were living alone, for supervised interventions including resistance exercise and when session duration was >60 min. Exercise effects on aerobic fitness were larger for younger patients and when supervised interventions included aerobic exercise. Conclusion Exercise interventions during and following cancer treatment had small effects on UBMS, LBMS, LBMF and aerobic fitness. Demographic, intervention-related and exercise-related characteristics including age, marital status, intervention timing, delivery mode and frequency and type and time of exercise sessions moderated the exercise effect on UBMS, LBMS and aerobic fitness.

AB - Objective To optimally target exercise interventions for patients with cancer, it is important to identify which patients benefit from which interventions. Design We conducted an individual patient data meta-analysis to investigate demographic, clinical, intervention-related and exercise-related moderators of exercise intervention effects on physical fitness in patients with cancer. Data sources We identified relevant studies via systematic searches in electronic databases (PubMed, Embase, PsycINFO and CINAHL). Eligibility criteria We analysed data from 28 randomised controlled trials investigating the effects of exercise on upper body muscle strength (UBMS) and lower body muscle strength (LBMS), lower body muscle function (LBMF) and aerobic fitness in adult patients with cancer. Results Exercise significantly improved UBMS (β=0.20, 95% Confidence Interval (CI) 0.14 to 0.26), LBMS (β=0.29, 95% CI 0.23 to 0.35), LBMF (β=0.16, 95% CI 0.08 to 0.24) and aerobic fitness (β=0.28, 95% CI 0.23 to 0.34), with larger effects for supervised interventions. Exercise effects on UBMS were larger during treatment, when supervised interventions included ≥3 sessions per week, when resistance exercises were included and when session duration was >60 min. Exercise effects on LBMS were larger for patients who were living alone, for supervised interventions including resistance exercise and when session duration was >60 min. Exercise effects on aerobic fitness were larger for younger patients and when supervised interventions included aerobic exercise. Conclusion Exercise interventions during and following cancer treatment had small effects on UBMS, LBMS, LBMF and aerobic fitness. Demographic, intervention-related and exercise-related characteristics including age, marital status, intervention timing, delivery mode and frequency and type and time of exercise sessions moderated the exercise effect on UBMS, LBMS and aerobic fitness.

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UR - http://www.scopus.com/inward/citedby.url?scp=85053110557&partnerID=8YFLogxK

U2 - 10.1136/bjsports-2018-099191

DO - 10.1136/bjsports-2018-099191

M3 - Review article

VL - 53

JO - British Journal of Sports Medicine

JF - British Journal of Sports Medicine

SN - 0306-3674

IS - 13

ER -