Effects of 18 days of bed rest on leg and arm venous properties

M. W P Bleeker, P. C E De Groot, James Anthony Pawelczyk, M. T E Hopman, B. D. Levine

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Venous function may be altered by bed rest deconditioning. Yet the contribution of altered venous compliance to the orthostatic intolerance observed after bed rest is uncertain. The purpose of this study was to assess the effect of 18 days of bed rest on leg and arm (respectively large and small change in gravitational gradients and use patterns) venous properties. We hypothesized that the magnitude of these venous changes would be related to orthostatic intolerance. Eleven healthy subjects (10 men, 1 woman) participated in the study. Before (pre) and after (post) 18 days of 6° head-down tilt bed rest, strain gauge venous occlusion plethysmography was used to assess limb venous vascular characteristics. Leg venous compliance was significantly decreased after bed rest (pre: 0.048 ± 0.007 ml·100 ml -1·mmHg-1, post: 0.033 ± 0.007 ml·100 ml-1; P < 0.01), whereas arm compliance did not change. Leg venous flow resistance increased significantly after bed rest (pre: 1.73 ± 1.08 mmHg·ml-1·100 ml·min, post: 3.10 ± 1.00 mmHg·ml-1·100 ml·min; P < 0.05). Maximal lower body negative pressure tolerance, which was expressed as cumulative stress index (pressure·time), decreased in all subjects after bed rest (pre: 932 mmHg·min, post: 747 mmHg·min). The decrease in orthostatic tolerance was not related to changes in leg venous compliance. In conclusion, this study demonstrates that after bed rest, leg venous compliance is reduced and leg venous outflow resistance is enhanced. However, these changes are not related to measures of orthostatic tolerance; therefore, alterations in venous compliance do not to play a major role in orthostatic intolerance after 18 days of head-down tilt bed rest.

Original languageEnglish (US)
Pages (from-to)840-847
Number of pages8
JournalJournal of Applied Physiology
Volume96
Issue number3
DOIs
StatePublished - Mar 1 2004

Fingerprint

Bed Rest
Leg
Arm
Orthostatic Intolerance
Compliance
Head-Down Tilt
Lower Body Negative Pressure
Plethysmography
Blood Vessels
Healthy Volunteers
Extremities

All Science Journal Classification (ASJC) codes

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Bleeker, M. W P ; De Groot, P. C E ; Pawelczyk, James Anthony ; Hopman, M. T E ; Levine, B. D. / Effects of 18 days of bed rest on leg and arm venous properties. In: Journal of Applied Physiology. 2004 ; Vol. 96, No. 3. pp. 840-847.
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Effects of 18 days of bed rest on leg and arm venous properties. / Bleeker, M. W P; De Groot, P. C E; Pawelczyk, James Anthony; Hopman, M. T E; Levine, B. D.

In: Journal of Applied Physiology, Vol. 96, No. 3, 01.03.2004, p. 840-847.

Research output: Contribution to journalArticle

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