Effects of a 9-month strength training intervention on insulin, insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and IGFBP-3 in 30-50-year-old women

Kathryn Schmitz, Rehana L. Ahmed, Douglas Yee

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Abstract

We assessed the effects of twice weekly strength training on several proposed risk factors for breast and colon cancer: body fat, waist circumference, fasting insulin, fasting glucose, insulin-like growth factor I (IGF-I), and several IGF-binding proteins. Fifty-four healthy women, 30-50 years old, were randomized to no-contact control or treatment: 15 weeks of supervised strength training followed by 6 months of unsupervised training. Fifteen-week changes included reductions in percentage of body fat, fasting insulin, fasting glucose, and IGF-I that were larger in the treatment than control participants (treatment versus control mean ± SE: % body fat -1.97 ± 0.42 versus -0.43 ± 0.40, P = 0.01; insulin (uU/ml) -0.29 ± 0.35 versus 0.81 ± 0.38, P = 0.055; glucose (mg/dl) -1.92 ± 1.27 versus 1.21 ± 1.36, P = 0.13; and IGF-I (ng/ml) -30.47 ± 9.75 versus 5.86 ± 10.44, P = 0.02). There was no treatment effect on IGF-binding proteins 1 and 3 or either of two surrogate measures of free IGF-I. By 39 weeks changes in percentages of body fat were largely maintained; IGF-I returned to baseline levels in the treatment group but remained 15% lower in treatment compared with control participants. Strength training produced favorable changes in several proposed cancer risk factors. The importance of these changes to long-term cancer prognosis, diagnosis, and/or recurrence remains to be determined.

Original languageEnglish (US)
Pages (from-to)1597-1604
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume11
Issue number12
StatePublished - Dec 1 2002

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Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor Binding Protein 3
Resistance Training
Insulin-Like Growth Factor I
Insulin
Adipose Tissue
Fasting
Glucose
Therapeutics
Insulin-Like Growth Factor Binding Proteins
Waist Circumference
Colonic Neoplasms
Neoplasms
Breast Neoplasms
Recurrence

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

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title = "Effects of a 9-month strength training intervention on insulin, insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and IGFBP-3 in 30-50-year-old women",
abstract = "We assessed the effects of twice weekly strength training on several proposed risk factors for breast and colon cancer: body fat, waist circumference, fasting insulin, fasting glucose, insulin-like growth factor I (IGF-I), and several IGF-binding proteins. Fifty-four healthy women, 30-50 years old, were randomized to no-contact control or treatment: 15 weeks of supervised strength training followed by 6 months of unsupervised training. Fifteen-week changes included reductions in percentage of body fat, fasting insulin, fasting glucose, and IGF-I that were larger in the treatment than control participants (treatment versus control mean ± SE: {\%} body fat -1.97 ± 0.42 versus -0.43 ± 0.40, P = 0.01; insulin (uU/ml) -0.29 ± 0.35 versus 0.81 ± 0.38, P = 0.055; glucose (mg/dl) -1.92 ± 1.27 versus 1.21 ± 1.36, P = 0.13; and IGF-I (ng/ml) -30.47 ± 9.75 versus 5.86 ± 10.44, P = 0.02). There was no treatment effect on IGF-binding proteins 1 and 3 or either of two surrogate measures of free IGF-I. By 39 weeks changes in percentages of body fat were largely maintained; IGF-I returned to baseline levels in the treatment group but remained 15{\%} lower in treatment compared with control participants. Strength training produced favorable changes in several proposed cancer risk factors. The importance of these changes to long-term cancer prognosis, diagnosis, and/or recurrence remains to be determined.",
author = "Kathryn Schmitz and Ahmed, {Rehana L.} and Douglas Yee",
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AU - Yee, Douglas

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N2 - We assessed the effects of twice weekly strength training on several proposed risk factors for breast and colon cancer: body fat, waist circumference, fasting insulin, fasting glucose, insulin-like growth factor I (IGF-I), and several IGF-binding proteins. Fifty-four healthy women, 30-50 years old, were randomized to no-contact control or treatment: 15 weeks of supervised strength training followed by 6 months of unsupervised training. Fifteen-week changes included reductions in percentage of body fat, fasting insulin, fasting glucose, and IGF-I that were larger in the treatment than control participants (treatment versus control mean ± SE: % body fat -1.97 ± 0.42 versus -0.43 ± 0.40, P = 0.01; insulin (uU/ml) -0.29 ± 0.35 versus 0.81 ± 0.38, P = 0.055; glucose (mg/dl) -1.92 ± 1.27 versus 1.21 ± 1.36, P = 0.13; and IGF-I (ng/ml) -30.47 ± 9.75 versus 5.86 ± 10.44, P = 0.02). There was no treatment effect on IGF-binding proteins 1 and 3 or either of two surrogate measures of free IGF-I. By 39 weeks changes in percentages of body fat were largely maintained; IGF-I returned to baseline levels in the treatment group but remained 15% lower in treatment compared with control participants. Strength training produced favorable changes in several proposed cancer risk factors. The importance of these changes to long-term cancer prognosis, diagnosis, and/or recurrence remains to be determined.

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