Effects of acute dietary nitrate supplementation on aortic blood pressures and pulse wave characteristics in post-menopausal women

Danielle Jin Kwang Kim, Carly A. Roe, Yasina B. Somani, David Moore, Megan A. Barrett, Michael Flanagan, Daniel B. Kim-Shapiro, Swati Basu, Matthew D. Muller, David Nathan Proctor

Research output: Contribution to journalArticle

Abstract

Purpose: Consumption of nitrate-rich beetroot juice can lower blood pressure in peripheral as well as central arteries and may exert additional hemodynamic benefits (e.g. reduced aortic wave reflections). The specific influence of nitrate supplementation on arterial pressures and aortic wave properties in postmenopausal women, a group that experiences accelerated increases in these variables with age, is unknown. Accordingly, the primary aim of this study was to determine the effect of consuming nitrate-rich beetroot juice on resting brachial and aortic blood pressures (BP) and pulse wave characteristics in a group of healthy postmenopausal women, in comparison to a true (nitrate-free beetroot juice) placebo. Methods: Brachial (oscillometric cuff) and radial (SphygmoCor) pressures and derived-aortic waveforms were measured during supine rest in thirteen healthy postmenopausal women (63 ± 1 yr) before and 100 min after consumption of 140 ml of either nitrate-rich (9.7 mmol, 0.6 gm NO 3 ) or nitrate-depleted beetroot juice on randomized visits approximately 10 days apart (cross-over design). Ten young premenopausal women (22 ± 1 yr) served as a reference (non-supplemented) cohort. Results: Brachial and derived-aortic variables showed the expected age-associated differences in these women (all p < 0.05). In post-menopausal women, nitrate supplementation reduced (p < 0.05 vs. placebo visit) brachial systolic BP (BR nitrate −4.9 ± 2.1 mmHg vs BR placebo +1.1 ± 1.8 mmHg), brachial mean BP (BR nitrate −4.1 ± 1.7 mmHg vs BR placebo +0.9 ± 1.3 mmHg), aortic systolic BP (BR nitrate −6.3 ± 2.0 mmHg vs BR placebo +0.5 ± 1.7 mmHg) and aortic mean BP (BR nitrate −4.1 ± 1.7 mmHg vs BR placebo +0.9 ± 1.3 mmHg), and increased pulse pressure amplification (BR nitrate +4.6 ± 2.0% vs BR placebo +0.7 ± 2.5%, p = 0.04), but did not alter aortic pulse wave velocity or any other derived-aortic variables (e.g., augmentation pressure or index). Conclusions: Dietary nitrate supplementation favorably modifies aortic systolic and mean blood pressure under resting conditions in healthy postmenopausal women. Acute supplementation of nitrate does not, however, appear to restore indices of aortic stiffness in this group. Future work should evaluate chronic, long-term effects of this non-pharmacological supplement.

Original languageEnglish (US)
Pages (from-to)10-16
Number of pages7
JournalNitric Oxide - Biology and Chemistry
Volume85
DOIs
StatePublished - Apr 1 2019

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Blood pressure
Dietary Supplements
Nitrates
Pulse
Arterial Pressure
Placebos
Blood Pressure
Arm
Pulse Wave Analysis
Vascular Stiffness
Hemodynamics
Cross-Over Studies
Amplification

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cancer Research

Cite this

Kim, Danielle Jin Kwang ; Roe, Carly A. ; Somani, Yasina B. ; Moore, David ; Barrett, Megan A. ; Flanagan, Michael ; Kim-Shapiro, Daniel B. ; Basu, Swati ; Muller, Matthew D. ; Proctor, David Nathan. / Effects of acute dietary nitrate supplementation on aortic blood pressures and pulse wave characteristics in post-menopausal women. In: Nitric Oxide - Biology and Chemistry. 2019 ; Vol. 85. pp. 10-16.
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title = "Effects of acute dietary nitrate supplementation on aortic blood pressures and pulse wave characteristics in post-menopausal women",
abstract = "Purpose: Consumption of nitrate-rich beetroot juice can lower blood pressure in peripheral as well as central arteries and may exert additional hemodynamic benefits (e.g. reduced aortic wave reflections). The specific influence of nitrate supplementation on arterial pressures and aortic wave properties in postmenopausal women, a group that experiences accelerated increases in these variables with age, is unknown. Accordingly, the primary aim of this study was to determine the effect of consuming nitrate-rich beetroot juice on resting brachial and aortic blood pressures (BP) and pulse wave characteristics in a group of healthy postmenopausal women, in comparison to a true (nitrate-free beetroot juice) placebo. Methods: Brachial (oscillometric cuff) and radial (SphygmoCor) pressures and derived-aortic waveforms were measured during supine rest in thirteen healthy postmenopausal women (63 ± 1 yr) before and 100 min after consumption of 140 ml of either nitrate-rich (9.7 mmol, 0.6 gm NO 3 − ) or nitrate-depleted beetroot juice on randomized visits approximately 10 days apart (cross-over design). Ten young premenopausal women (22 ± 1 yr) served as a reference (non-supplemented) cohort. Results: Brachial and derived-aortic variables showed the expected age-associated differences in these women (all p < 0.05). In post-menopausal women, nitrate supplementation reduced (p < 0.05 vs. placebo visit) brachial systolic BP (BR nitrate −4.9 ± 2.1 mmHg vs BR placebo +1.1 ± 1.8 mmHg), brachial mean BP (BR nitrate −4.1 ± 1.7 mmHg vs BR placebo +0.9 ± 1.3 mmHg), aortic systolic BP (BR nitrate −6.3 ± 2.0 mmHg vs BR placebo +0.5 ± 1.7 mmHg) and aortic mean BP (BR nitrate −4.1 ± 1.7 mmHg vs BR placebo +0.9 ± 1.3 mmHg), and increased pulse pressure amplification (BR nitrate +4.6 ± 2.0{\%} vs BR placebo +0.7 ± 2.5{\%}, p = 0.04), but did not alter aortic pulse wave velocity or any other derived-aortic variables (e.g., augmentation pressure or index). Conclusions: Dietary nitrate supplementation favorably modifies aortic systolic and mean blood pressure under resting conditions in healthy postmenopausal women. Acute supplementation of nitrate does not, however, appear to restore indices of aortic stiffness in this group. Future work should evaluate chronic, long-term effects of this non-pharmacological supplement.",
author = "Kim, {Danielle Jin Kwang} and Roe, {Carly A.} and Somani, {Yasina B.} and David Moore and Barrett, {Megan A.} and Michael Flanagan and Kim-Shapiro, {Daniel B.} and Swati Basu and Muller, {Matthew D.} and Proctor, {David Nathan}",
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language = "English (US)",
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pages = "10--16",
journal = "Nitric Oxide - Biology and Chemistry",
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Effects of acute dietary nitrate supplementation on aortic blood pressures and pulse wave characteristics in post-menopausal women. / Kim, Danielle Jin Kwang; Roe, Carly A.; Somani, Yasina B.; Moore, David; Barrett, Megan A.; Flanagan, Michael; Kim-Shapiro, Daniel B.; Basu, Swati; Muller, Matthew D.; Proctor, David Nathan.

In: Nitric Oxide - Biology and Chemistry, Vol. 85, 01.04.2019, p. 10-16.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of acute dietary nitrate supplementation on aortic blood pressures and pulse wave characteristics in post-menopausal women

AU - Kim, Danielle Jin Kwang

AU - Roe, Carly A.

AU - Somani, Yasina B.

AU - Moore, David

AU - Barrett, Megan A.

AU - Flanagan, Michael

AU - Kim-Shapiro, Daniel B.

AU - Basu, Swati

AU - Muller, Matthew D.

AU - Proctor, David Nathan

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Purpose: Consumption of nitrate-rich beetroot juice can lower blood pressure in peripheral as well as central arteries and may exert additional hemodynamic benefits (e.g. reduced aortic wave reflections). The specific influence of nitrate supplementation on arterial pressures and aortic wave properties in postmenopausal women, a group that experiences accelerated increases in these variables with age, is unknown. Accordingly, the primary aim of this study was to determine the effect of consuming nitrate-rich beetroot juice on resting brachial and aortic blood pressures (BP) and pulse wave characteristics in a group of healthy postmenopausal women, in comparison to a true (nitrate-free beetroot juice) placebo. Methods: Brachial (oscillometric cuff) and radial (SphygmoCor) pressures and derived-aortic waveforms were measured during supine rest in thirteen healthy postmenopausal women (63 ± 1 yr) before and 100 min after consumption of 140 ml of either nitrate-rich (9.7 mmol, 0.6 gm NO 3 − ) or nitrate-depleted beetroot juice on randomized visits approximately 10 days apart (cross-over design). Ten young premenopausal women (22 ± 1 yr) served as a reference (non-supplemented) cohort. Results: Brachial and derived-aortic variables showed the expected age-associated differences in these women (all p < 0.05). In post-menopausal women, nitrate supplementation reduced (p < 0.05 vs. placebo visit) brachial systolic BP (BR nitrate −4.9 ± 2.1 mmHg vs BR placebo +1.1 ± 1.8 mmHg), brachial mean BP (BR nitrate −4.1 ± 1.7 mmHg vs BR placebo +0.9 ± 1.3 mmHg), aortic systolic BP (BR nitrate −6.3 ± 2.0 mmHg vs BR placebo +0.5 ± 1.7 mmHg) and aortic mean BP (BR nitrate −4.1 ± 1.7 mmHg vs BR placebo +0.9 ± 1.3 mmHg), and increased pulse pressure amplification (BR nitrate +4.6 ± 2.0% vs BR placebo +0.7 ± 2.5%, p = 0.04), but did not alter aortic pulse wave velocity or any other derived-aortic variables (e.g., augmentation pressure or index). Conclusions: Dietary nitrate supplementation favorably modifies aortic systolic and mean blood pressure under resting conditions in healthy postmenopausal women. Acute supplementation of nitrate does not, however, appear to restore indices of aortic stiffness in this group. Future work should evaluate chronic, long-term effects of this non-pharmacological supplement.

AB - Purpose: Consumption of nitrate-rich beetroot juice can lower blood pressure in peripheral as well as central arteries and may exert additional hemodynamic benefits (e.g. reduced aortic wave reflections). The specific influence of nitrate supplementation on arterial pressures and aortic wave properties in postmenopausal women, a group that experiences accelerated increases in these variables with age, is unknown. Accordingly, the primary aim of this study was to determine the effect of consuming nitrate-rich beetroot juice on resting brachial and aortic blood pressures (BP) and pulse wave characteristics in a group of healthy postmenopausal women, in comparison to a true (nitrate-free beetroot juice) placebo. Methods: Brachial (oscillometric cuff) and radial (SphygmoCor) pressures and derived-aortic waveforms were measured during supine rest in thirteen healthy postmenopausal women (63 ± 1 yr) before and 100 min after consumption of 140 ml of either nitrate-rich (9.7 mmol, 0.6 gm NO 3 − ) or nitrate-depleted beetroot juice on randomized visits approximately 10 days apart (cross-over design). Ten young premenopausal women (22 ± 1 yr) served as a reference (non-supplemented) cohort. Results: Brachial and derived-aortic variables showed the expected age-associated differences in these women (all p < 0.05). In post-menopausal women, nitrate supplementation reduced (p < 0.05 vs. placebo visit) brachial systolic BP (BR nitrate −4.9 ± 2.1 mmHg vs BR placebo +1.1 ± 1.8 mmHg), brachial mean BP (BR nitrate −4.1 ± 1.7 mmHg vs BR placebo +0.9 ± 1.3 mmHg), aortic systolic BP (BR nitrate −6.3 ± 2.0 mmHg vs BR placebo +0.5 ± 1.7 mmHg) and aortic mean BP (BR nitrate −4.1 ± 1.7 mmHg vs BR placebo +0.9 ± 1.3 mmHg), and increased pulse pressure amplification (BR nitrate +4.6 ± 2.0% vs BR placebo +0.7 ± 2.5%, p = 0.04), but did not alter aortic pulse wave velocity or any other derived-aortic variables (e.g., augmentation pressure or index). Conclusions: Dietary nitrate supplementation favorably modifies aortic systolic and mean blood pressure under resting conditions in healthy postmenopausal women. Acute supplementation of nitrate does not, however, appear to restore indices of aortic stiffness in this group. Future work should evaluate chronic, long-term effects of this non-pharmacological supplement.

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