Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women

Jackie A. Lavigne, David J. Baer, Heather H. Wimbrow, Paul S. Albert, Ellen D. Brown, Joseph T. Judd, William S. Campbell, Carol A. Giffen, Joanne F. Dorgan, Terryl J. Hartman, J. Carl Barrett, Stephen D. Hursting, Philip R. Taylor

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20 Citations (Scopus)

Abstract

Background: Increased circulating insulin-like growth factor I (IGF-I) concentrations, frequently adjusted for IGF binding protein 3 (IGFBP-3), have been associated with increased risk of several types of cancer, including colon, prostate, and breast. Studies have suggested that alcohol may affect IGF-I or IGFBP-3; however, controlled feeding studies to assess alcohol's effects on IGF-I or IGFBP-3 have not been conducted. Objective: To determine whether chronic, moderate alcohol intake affects serum IGF-I or IGFBP-3 concentrations, we performed a controlled, crossover feeding study. Design: Fifty-three postmenopausal women were randomly assigned to consume 0 g (control), 15 g (one drink), or 30 g (2 drinks) alcohol daily for 8 wk and were rotated through the other 2 intake levels in random order. All foods and beverages were provided during the intervention. Individuals were monitored and calories adjusted to maintain constant weight, and serum was collected at the end of each diet period. Results: Compared with the effects of 0 g alcohol/d, IGF-I concentrations were nearly unchanged by 15 g alcohol/d (0.8%; 95% CI: -3.2%, 3.5%) but decreased significantly by 4.9% (95% CI: -8.0%, -1.6%) with 30 g alcohol/d. IGFBP-3 concentrations significantly increased by 3.0% (95% CI: 0.4%, 5.6%) with 15 g alcohol/d but did not increase significantly with 30 g/d (1.8%; 95% CI: -0.9%, 4.5%). Conclusions: To our knowledge, this is the first published controlled diet study to find that in postmenopausal women, when weight is kept constant, alcohol consumption reduces the amount of serum IGF-I potentially available for receptor binding. These findings suggest that the effect of alcohol intake should be considered in studies of IGF-I, IGFBP-3, and cancer in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)503-507
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume81
Issue number2
StatePublished - Dec 1 2005

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Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Alcohols
Serum
Diet
Weights and Measures
Food and Beverages
Alcohol Drinking
Colonic Neoplasms
Cross-Over Studies
Prostate
Breast

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Lavigne, J. A., Baer, D. J., Wimbrow, H. H., Albert, P. S., Brown, E. D., Judd, J. T., ... Taylor, P. R. (2005). Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women. American Journal of Clinical Nutrition, 81(2), 503-507.
Lavigne, Jackie A. ; Baer, David J. ; Wimbrow, Heather H. ; Albert, Paul S. ; Brown, Ellen D. ; Judd, Joseph T. ; Campbell, William S. ; Giffen, Carol A. ; Dorgan, Joanne F. ; Hartman, Terryl J. ; Barrett, J. Carl ; Hursting, Stephen D. ; Taylor, Philip R. / Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women. In: American Journal of Clinical Nutrition. 2005 ; Vol. 81, No. 2. pp. 503-507.
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title = "Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women",
abstract = "Background: Increased circulating insulin-like growth factor I (IGF-I) concentrations, frequently adjusted for IGF binding protein 3 (IGFBP-3), have been associated with increased risk of several types of cancer, including colon, prostate, and breast. Studies have suggested that alcohol may affect IGF-I or IGFBP-3; however, controlled feeding studies to assess alcohol's effects on IGF-I or IGFBP-3 have not been conducted. Objective: To determine whether chronic, moderate alcohol intake affects serum IGF-I or IGFBP-3 concentrations, we performed a controlled, crossover feeding study. Design: Fifty-three postmenopausal women were randomly assigned to consume 0 g (control), 15 g (one drink), or 30 g (2 drinks) alcohol daily for 8 wk and were rotated through the other 2 intake levels in random order. All foods and beverages were provided during the intervention. Individuals were monitored and calories adjusted to maintain constant weight, and serum was collected at the end of each diet period. Results: Compared with the effects of 0 g alcohol/d, IGF-I concentrations were nearly unchanged by 15 g alcohol/d (0.8{\%}; 95{\%} CI: -3.2{\%}, 3.5{\%}) but decreased significantly by 4.9{\%} (95{\%} CI: -8.0{\%}, -1.6{\%}) with 30 g alcohol/d. IGFBP-3 concentrations significantly increased by 3.0{\%} (95{\%} CI: 0.4{\%}, 5.6{\%}) with 15 g alcohol/d but did not increase significantly with 30 g/d (1.8{\%}; 95{\%} CI: -0.9{\%}, 4.5{\%}). Conclusions: To our knowledge, this is the first published controlled diet study to find that in postmenopausal women, when weight is kept constant, alcohol consumption reduces the amount of serum IGF-I potentially available for receptor binding. These findings suggest that the effect of alcohol intake should be considered in studies of IGF-I, IGFBP-3, and cancer in postmenopausal women.",
author = "Lavigne, {Jackie A.} and Baer, {David J.} and Wimbrow, {Heather H.} and Albert, {Paul S.} and Brown, {Ellen D.} and Judd, {Joseph T.} and Campbell, {William S.} and Giffen, {Carol A.} and Dorgan, {Joanne F.} and Hartman, {Terryl J.} and Barrett, {J. Carl} and Hursting, {Stephen D.} and Taylor, {Philip R.}",
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Lavigne, JA, Baer, DJ, Wimbrow, HH, Albert, PS, Brown, ED, Judd, JT, Campbell, WS, Giffen, CA, Dorgan, JF, Hartman, TJ, Barrett, JC, Hursting, SD & Taylor, PR 2005, 'Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women', American Journal of Clinical Nutrition, vol. 81, no. 2, pp. 503-507.

Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women. / Lavigne, Jackie A.; Baer, David J.; Wimbrow, Heather H.; Albert, Paul S.; Brown, Ellen D.; Judd, Joseph T.; Campbell, William S.; Giffen, Carol A.; Dorgan, Joanne F.; Hartman, Terryl J.; Barrett, J. Carl; Hursting, Stephen D.; Taylor, Philip R.

In: American Journal of Clinical Nutrition, Vol. 81, No. 2, 01.12.2005, p. 503-507.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women

AU - Lavigne, Jackie A.

AU - Baer, David J.

AU - Wimbrow, Heather H.

AU - Albert, Paul S.

AU - Brown, Ellen D.

AU - Judd, Joseph T.

AU - Campbell, William S.

AU - Giffen, Carol A.

AU - Dorgan, Joanne F.

AU - Hartman, Terryl J.

AU - Barrett, J. Carl

AU - Hursting, Stephen D.

AU - Taylor, Philip R.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Background: Increased circulating insulin-like growth factor I (IGF-I) concentrations, frequently adjusted for IGF binding protein 3 (IGFBP-3), have been associated with increased risk of several types of cancer, including colon, prostate, and breast. Studies have suggested that alcohol may affect IGF-I or IGFBP-3; however, controlled feeding studies to assess alcohol's effects on IGF-I or IGFBP-3 have not been conducted. Objective: To determine whether chronic, moderate alcohol intake affects serum IGF-I or IGFBP-3 concentrations, we performed a controlled, crossover feeding study. Design: Fifty-three postmenopausal women were randomly assigned to consume 0 g (control), 15 g (one drink), or 30 g (2 drinks) alcohol daily for 8 wk and were rotated through the other 2 intake levels in random order. All foods and beverages were provided during the intervention. Individuals were monitored and calories adjusted to maintain constant weight, and serum was collected at the end of each diet period. Results: Compared with the effects of 0 g alcohol/d, IGF-I concentrations were nearly unchanged by 15 g alcohol/d (0.8%; 95% CI: -3.2%, 3.5%) but decreased significantly by 4.9% (95% CI: -8.0%, -1.6%) with 30 g alcohol/d. IGFBP-3 concentrations significantly increased by 3.0% (95% CI: 0.4%, 5.6%) with 15 g alcohol/d but did not increase significantly with 30 g/d (1.8%; 95% CI: -0.9%, 4.5%). Conclusions: To our knowledge, this is the first published controlled diet study to find that in postmenopausal women, when weight is kept constant, alcohol consumption reduces the amount of serum IGF-I potentially available for receptor binding. These findings suggest that the effect of alcohol intake should be considered in studies of IGF-I, IGFBP-3, and cancer in postmenopausal women.

AB - Background: Increased circulating insulin-like growth factor I (IGF-I) concentrations, frequently adjusted for IGF binding protein 3 (IGFBP-3), have been associated with increased risk of several types of cancer, including colon, prostate, and breast. Studies have suggested that alcohol may affect IGF-I or IGFBP-3; however, controlled feeding studies to assess alcohol's effects on IGF-I or IGFBP-3 have not been conducted. Objective: To determine whether chronic, moderate alcohol intake affects serum IGF-I or IGFBP-3 concentrations, we performed a controlled, crossover feeding study. Design: Fifty-three postmenopausal women were randomly assigned to consume 0 g (control), 15 g (one drink), or 30 g (2 drinks) alcohol daily for 8 wk and were rotated through the other 2 intake levels in random order. All foods and beverages were provided during the intervention. Individuals were monitored and calories adjusted to maintain constant weight, and serum was collected at the end of each diet period. Results: Compared with the effects of 0 g alcohol/d, IGF-I concentrations were nearly unchanged by 15 g alcohol/d (0.8%; 95% CI: -3.2%, 3.5%) but decreased significantly by 4.9% (95% CI: -8.0%, -1.6%) with 30 g alcohol/d. IGFBP-3 concentrations significantly increased by 3.0% (95% CI: 0.4%, 5.6%) with 15 g alcohol/d but did not increase significantly with 30 g/d (1.8%; 95% CI: -0.9%, 4.5%). Conclusions: To our knowledge, this is the first published controlled diet study to find that in postmenopausal women, when weight is kept constant, alcohol consumption reduces the amount of serum IGF-I potentially available for receptor binding. These findings suggest that the effect of alcohol intake should be considered in studies of IGF-I, IGFBP-3, and cancer in postmenopausal women.

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