Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk

Anqi Qiu, Mojun Shen, Claudia Buss, Yap Seng Chong, Kenneth Kwek, Seang Mei Saw, Peter D. Gluckman, Pathik D. Wadhwa, Sonja Entringer, Martin Styner, Neerja Karnani, Christine Marcelle Heim, Kieran J. O'donnell, Joanna D. Holbrook, Marielle V. Fortier, Michael J. Meaney

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This study included 168 and 85 mother-infant dyads from Asian and United States of America cohorts to examine whether a genomic profile risk score for major depressive disorder (GPRSMDD) moderates the association between antenatal maternal depressive symptoms (or socio-economic status, SES) and fetal neurodevelopment, and to identify candidate biological processes underlying such association. Both cohorts showed a significant interaction between antenatal maternal depressive symptoms and infant GPRSMDD on the right amygdala volume. The Asian cohort also showed such interaction on the right hippocampal volume and shape, thickness of the orbitofrontal and ventromedial prefrontal cortex. Likewise, a significant interaction between SES and infant GPRSMDD was on the right amygdala and hippocampal volumes and shapes. After controlling for each other, the interaction effect of antenatal maternal depressive symptoms and GPRSMDD was mainly shown on the right amygdala, while the interaction effect of SES and GPRSMDD was mainly shown on the right hippocampus. Bioinformatic analyses suggested neurotransmitter/neurotrophic signaling, SNAp REceptor complex, and glutamate receptor activity as common biological processes underlying the influence of antenatal maternal depressive symptoms on fetal cortico-limbic development. These findings suggest gene-environment interdependence in the fetal development of brain regions implicated in cognitive-emotional function. Candidate biological mechanisms involve a range of brain region-specific signaling pathways that converge on common processes of synaptic development.

Original languageEnglish (US)
Pages (from-to)3080-3092
Number of pages13
JournalCerebral Cortex
Volume27
Issue number5
DOIs
StatePublished - May 1 2017

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Major Depressive Disorder
Economics
Mothers
Depression
Amygdala
Brain
Biological Phenomena
Glutamate Receptors
Fetal Development
Prefrontal Cortex
Computational Biology
Cognition
Neurotransmitter Agents
Hippocampus
Genes

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Qiu, Anqi ; Shen, Mojun ; Buss, Claudia ; Chong, Yap Seng ; Kwek, Kenneth ; Saw, Seang Mei ; Gluckman, Peter D. ; Wadhwa, Pathik D. ; Entringer, Sonja ; Styner, Martin ; Karnani, Neerja ; Heim, Christine Marcelle ; O'donnell, Kieran J. ; Holbrook, Joanna D. ; Fortier, Marielle V. ; Meaney, Michael J. / Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk. In: Cerebral Cortex. 2017 ; Vol. 27, No. 5. pp. 3080-3092.
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abstract = "This study included 168 and 85 mother-infant dyads from Asian and United States of America cohorts to examine whether a genomic profile risk score for major depressive disorder (GPRSMDD) moderates the association between antenatal maternal depressive symptoms (or socio-economic status, SES) and fetal neurodevelopment, and to identify candidate biological processes underlying such association. Both cohorts showed a significant interaction between antenatal maternal depressive symptoms and infant GPRSMDD on the right amygdala volume. The Asian cohort also showed such interaction on the right hippocampal volume and shape, thickness of the orbitofrontal and ventromedial prefrontal cortex. Likewise, a significant interaction between SES and infant GPRSMDD was on the right amygdala and hippocampal volumes and shapes. After controlling for each other, the interaction effect of antenatal maternal depressive symptoms and GPRSMDD was mainly shown on the right amygdala, while the interaction effect of SES and GPRSMDD was mainly shown on the right hippocampus. Bioinformatic analyses suggested neurotransmitter/neurotrophic signaling, SNAp REceptor complex, and glutamate receptor activity as common biological processes underlying the influence of antenatal maternal depressive symptoms on fetal cortico-limbic development. These findings suggest gene-environment interdependence in the fetal development of brain regions implicated in cognitive-emotional function. Candidate biological mechanisms involve a range of brain region-specific signaling pathways that converge on common processes of synaptic development.",
author = "Anqi Qiu and Mojun Shen and Claudia Buss and Chong, {Yap Seng} and Kenneth Kwek and Saw, {Seang Mei} and Gluckman, {Peter D.} and Wadhwa, {Pathik D.} and Sonja Entringer and Martin Styner and Neerja Karnani and Heim, {Christine Marcelle} and O'donnell, {Kieran J.} and Holbrook, {Joanna D.} and Fortier, {Marielle V.} and Meaney, {Michael J.}",
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Qiu, A, Shen, M, Buss, C, Chong, YS, Kwek, K, Saw, SM, Gluckman, PD, Wadhwa, PD, Entringer, S, Styner, M, Karnani, N, Heim, CM, O'donnell, KJ, Holbrook, JD, Fortier, MV & Meaney, MJ 2017, 'Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk', Cerebral Cortex, vol. 27, no. 5, pp. 3080-3092. https://doi.org/10.1093/cercor/bhx065

Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk. / Qiu, Anqi; Shen, Mojun; Buss, Claudia; Chong, Yap Seng; Kwek, Kenneth; Saw, Seang Mei; Gluckman, Peter D.; Wadhwa, Pathik D.; Entringer, Sonja; Styner, Martin; Karnani, Neerja; Heim, Christine Marcelle; O'donnell, Kieran J.; Holbrook, Joanna D.; Fortier, Marielle V.; Meaney, Michael J.

In: Cerebral Cortex, Vol. 27, No. 5, 01.05.2017, p. 3080-3092.

Research output: Contribution to journalArticle

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T1 - Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk

AU - Qiu, Anqi

AU - Shen, Mojun

AU - Buss, Claudia

AU - Chong, Yap Seng

AU - Kwek, Kenneth

AU - Saw, Seang Mei

AU - Gluckman, Peter D.

AU - Wadhwa, Pathik D.

AU - Entringer, Sonja

AU - Styner, Martin

AU - Karnani, Neerja

AU - Heim, Christine Marcelle

AU - O'donnell, Kieran J.

AU - Holbrook, Joanna D.

AU - Fortier, Marielle V.

AU - Meaney, Michael J.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - This study included 168 and 85 mother-infant dyads from Asian and United States of America cohorts to examine whether a genomic profile risk score for major depressive disorder (GPRSMDD) moderates the association between antenatal maternal depressive symptoms (or socio-economic status, SES) and fetal neurodevelopment, and to identify candidate biological processes underlying such association. Both cohorts showed a significant interaction between antenatal maternal depressive symptoms and infant GPRSMDD on the right amygdala volume. The Asian cohort also showed such interaction on the right hippocampal volume and shape, thickness of the orbitofrontal and ventromedial prefrontal cortex. Likewise, a significant interaction between SES and infant GPRSMDD was on the right amygdala and hippocampal volumes and shapes. After controlling for each other, the interaction effect of antenatal maternal depressive symptoms and GPRSMDD was mainly shown on the right amygdala, while the interaction effect of SES and GPRSMDD was mainly shown on the right hippocampus. Bioinformatic analyses suggested neurotransmitter/neurotrophic signaling, SNAp REceptor complex, and glutamate receptor activity as common biological processes underlying the influence of antenatal maternal depressive symptoms on fetal cortico-limbic development. These findings suggest gene-environment interdependence in the fetal development of brain regions implicated in cognitive-emotional function. Candidate biological mechanisms involve a range of brain region-specific signaling pathways that converge on common processes of synaptic development.

AB - This study included 168 and 85 mother-infant dyads from Asian and United States of America cohorts to examine whether a genomic profile risk score for major depressive disorder (GPRSMDD) moderates the association between antenatal maternal depressive symptoms (or socio-economic status, SES) and fetal neurodevelopment, and to identify candidate biological processes underlying such association. Both cohorts showed a significant interaction between antenatal maternal depressive symptoms and infant GPRSMDD on the right amygdala volume. The Asian cohort also showed such interaction on the right hippocampal volume and shape, thickness of the orbitofrontal and ventromedial prefrontal cortex. Likewise, a significant interaction between SES and infant GPRSMDD was on the right amygdala and hippocampal volumes and shapes. After controlling for each other, the interaction effect of antenatal maternal depressive symptoms and GPRSMDD was mainly shown on the right amygdala, while the interaction effect of SES and GPRSMDD was mainly shown on the right hippocampus. Bioinformatic analyses suggested neurotransmitter/neurotrophic signaling, SNAp REceptor complex, and glutamate receptor activity as common biological processes underlying the influence of antenatal maternal depressive symptoms on fetal cortico-limbic development. These findings suggest gene-environment interdependence in the fetal development of brain regions implicated in cognitive-emotional function. Candidate biological mechanisms involve a range of brain region-specific signaling pathways that converge on common processes of synaptic development.

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