Effects of bilateral clamping of carotid arteries on hippocampal kindling in rats

Zuner A. Bortolotto; Christine Heim; Maria Sieklucka; Frank Block; Karl Heinz Sontag; Esper A. Cavalheiro

doi:10.1016/0031-9384(91)90299-4

Effects of bilateral clamping of carotid arteries on hippocampal kindling in rats

Zuner A. Bortolotto, Christine Heim, Maria Sieklucka, Frank Block, Karl Heinz Sontag, Esper A. Cavalheiro

Research output: Contribution to journal › Article

26 Scopus citations

Abstract

Moderate reduction of cerebral blood flow by bilateral clamping of carotid arteries (BCCA) in pentobarbital anaesthetized Wistar rats induces decreased PO₂ and temperature values in vulnerable brain structures such as hippocampus and frontal cortex during the acute phase of clamping. Up to two weeks chronic increased GABA contents in hippocampus, substantia nigra and frontal cortex could be observed. During this time the development of hippocampal kindling was difficult. These results demonstrated an acute and chronic influence of GABA on most vulnerable brain structures which, however, do not lead to ischemic impacts as histological analyses demonstrate.

Original language	English (US)
Pages (from-to)	667-671
Number of pages	5
Journal	Physiology and Behavior
Volume	49
Issue number	4
DOIs	https://doi.org/10.1016/0031-9384(91)90299-4
Publication status	Published - Apr 1991

Fingerprint

All Science Journal Classification (ASJC) codes

Experimental and Cognitive Psychology
Behavioral Neuroscience

Cite this

Bortolotto, Z. A., Heim, C., Sieklucka, M., Block, F., Sontag, K. H., & Cavalheiro, E. A. (1991). Effects of bilateral clamping of carotid arteries on hippocampal kindling in rats. Physiology and Behavior, 49(4), 667-671. https://doi.org/10.1016/0031-9384(91)90299-4

@article{46fd32f6e9fb41a7ba839df8444e2039,

title = "Effects of bilateral clamping of carotid arteries on hippocampal kindling in rats",

abstract = "Moderate reduction of cerebral blood flow by bilateral clamping of carotid arteries (BCCA) in pentobarbital anaesthetized Wistar rats induces decreased PO2 and temperature values in vulnerable brain structures such as hippocampus and frontal cortex during the acute phase of clamping. Up to two weeks chronic increased GABA contents in hippocampus, substantia nigra and frontal cortex could be observed. During this time the development of hippocampal kindling was difficult. These results demonstrated an acute and chronic influence of GABA on most vulnerable brain structures which, however, do not lead to ischemic impacts as histological analyses demonstrate.",

author = "Bortolotto, {Zuner A.} and Christine Heim and Maria Sieklucka and Frank Block and Sontag, {Karl Heinz} and Cavalheiro, {Esper A.}",

year = "1991",

month = "4",

doi = "10.1016/0031-9384(91)90299-4",

language = "English (US)",

volume = "49",

pages = "667--671",

journal = "Physiology and Behavior",

issn = "0031-9384",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Effects of bilateral clamping of carotid arteries on hippocampal kindling in rats

AU - Bortolotto, Zuner A.

AU - Heim, Christine

AU - Sieklucka, Maria

AU - Block, Frank

AU - Sontag, Karl Heinz

AU - Cavalheiro, Esper A.

PY - 1991/4

Y1 - 1991/4

N2 - Moderate reduction of cerebral blood flow by bilateral clamping of carotid arteries (BCCA) in pentobarbital anaesthetized Wistar rats induces decreased PO2 and temperature values in vulnerable brain structures such as hippocampus and frontal cortex during the acute phase of clamping. Up to two weeks chronic increased GABA contents in hippocampus, substantia nigra and frontal cortex could be observed. During this time the development of hippocampal kindling was difficult. These results demonstrated an acute and chronic influence of GABA on most vulnerable brain structures which, however, do not lead to ischemic impacts as histological analyses demonstrate.

AB - Moderate reduction of cerebral blood flow by bilateral clamping of carotid arteries (BCCA) in pentobarbital anaesthetized Wistar rats induces decreased PO2 and temperature values in vulnerable brain structures such as hippocampus and frontal cortex during the acute phase of clamping. Up to two weeks chronic increased GABA contents in hippocampus, substantia nigra and frontal cortex could be observed. During this time the development of hippocampal kindling was difficult. These results demonstrated an acute and chronic influence of GABA on most vulnerable brain structures which, however, do not lead to ischemic impacts as histological analyses demonstrate.

UR - http://www.scopus.com/inward/record.url?scp=0025779763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025779763&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(91)90299-4

DO - 10.1016/0031-9384(91)90299-4

M3 - Article

C2 - 1881967

AN - SCOPUS:0025779763

VL - 49

SP - 667

EP - 671

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 4

ER -

Access to Document

10.1016/0031-9384(91)90299-4