TY - JOUR
T1 - Effects of bilateral clamping of carotid arteries on hippocampal kindling in rats
AU - Bortolotto, Zuner A.
AU - Heim, Christine
AU - Sieklucka, Maria
AU - Block, Frank
AU - Sontag, Karl Heinz
AU - Cavalheiro, Esper A.
PY - 1991/4
Y1 - 1991/4
N2 - Moderate reduction of cerebral blood flow by bilateral clamping of carotid arteries (BCCA) in pentobarbital anaesthetized Wistar rats induces decreased PO2 and temperature values in vulnerable brain structures such as hippocampus and frontal cortex during the acute phase of clamping. Up to two weeks chronic increased GABA contents in hippocampus, substantia nigra and frontal cortex could be observed. During this time the development of hippocampal kindling was difficult. These results demonstrated an acute and chronic influence of GABA on most vulnerable brain structures which, however, do not lead to ischemic impacts as histological analyses demonstrate.
AB - Moderate reduction of cerebral blood flow by bilateral clamping of carotid arteries (BCCA) in pentobarbital anaesthetized Wistar rats induces decreased PO2 and temperature values in vulnerable brain structures such as hippocampus and frontal cortex during the acute phase of clamping. Up to two weeks chronic increased GABA contents in hippocampus, substantia nigra and frontal cortex could be observed. During this time the development of hippocampal kindling was difficult. These results demonstrated an acute and chronic influence of GABA on most vulnerable brain structures which, however, do not lead to ischemic impacts as histological analyses demonstrate.
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U2 - 10.1016/0031-9384(91)90299-4
DO - 10.1016/0031-9384(91)90299-4
M3 - Article
C2 - 1881967
AN - SCOPUS:0025779763
VL - 49
SP - 667
EP - 671
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 4
ER -