Effects of bleach reprocessing on hemodialysis membranes

Susanne H. Wolff, Andrew L. Zydney

Research output: Contribution to journalConference article

Abstract

Hemodialysis membranes are exposed to bleach during standard reprocessing methods, but there is little quantitative understanding of the effects of bleach on the mass transfer characteristics or surface properties of these membranes. A battery of experiments was used to evaluate the effects of bleach on the properties of Fresenius F80A, F80B, and Optiflux 180A dialyzers. Bleach caused a significant increase in the membrane hydraulic permeability. The clearance of urea (MW=60 Da) increased by only 3% after a 1-hour exposure to bleach at 50°C compared to more than a 10-fold increase in the clearance of a 15 kD MW dextran. The solute clearance data were used to determine the effective membrane pore size using available hydrodynamic models. Bleach caused a significant increase in the effective pore size, which was attributed to the leaching of the polyvinylpyrrolidone (PVP) out of the polysulfone membrane. Bleach also caused a significant increase in the magnitude of the negative charge on the membrane surface; the zeta potential varied from -4.1 mV for the new membrane to -13.0 mV after a 14-hour exposure to bleach. These changes in pore size and surface properties provide important insights into the effects of bleach on hemodialysis membranes.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalMaterials Research Society Symposium - Proceedings
Volume752
StatePublished - Jul 25 2003
EventMembranes Preparation Properties and Applications - Boston MA, United States
Duration: Dec 2 2002Dec 5 2002

Fingerprint

membranes
Membranes
clearances
Pore size
porosity
surface properties
Surface properties
Povidone
dextrans
Polysulfones
Dextran
Zeta potential
leaching
Dextrans
ureas
Urea
hydraulics
Leaching
mass transfer
electric batteries

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

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title = "Effects of bleach reprocessing on hemodialysis membranes",
abstract = "Hemodialysis membranes are exposed to bleach during standard reprocessing methods, but there is little quantitative understanding of the effects of bleach on the mass transfer characteristics or surface properties of these membranes. A battery of experiments was used to evaluate the effects of bleach on the properties of Fresenius F80A, F80B, and Optiflux 180A dialyzers. Bleach caused a significant increase in the membrane hydraulic permeability. The clearance of urea (MW=60 Da) increased by only 3{\%} after a 1-hour exposure to bleach at 50°C compared to more than a 10-fold increase in the clearance of a 15 kD MW dextran. The solute clearance data were used to determine the effective membrane pore size using available hydrodynamic models. Bleach caused a significant increase in the effective pore size, which was attributed to the leaching of the polyvinylpyrrolidone (PVP) out of the polysulfone membrane. Bleach also caused a significant increase in the magnitude of the negative charge on the membrane surface; the zeta potential varied from -4.1 mV for the new membrane to -13.0 mV after a 14-hour exposure to bleach. These changes in pore size and surface properties provide important insights into the effects of bleach on hemodialysis membranes.",
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Effects of bleach reprocessing on hemodialysis membranes. / Wolff, Susanne H.; Zydney, Andrew L.

In: Materials Research Society Symposium - Proceedings, Vol. 752, 25.07.2003, p. 297-302.

Research output: Contribution to journalConference article

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AU - Wolff, Susanne H.

AU - Zydney, Andrew L.

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AB - Hemodialysis membranes are exposed to bleach during standard reprocessing methods, but there is little quantitative understanding of the effects of bleach on the mass transfer characteristics or surface properties of these membranes. A battery of experiments was used to evaluate the effects of bleach on the properties of Fresenius F80A, F80B, and Optiflux 180A dialyzers. Bleach caused a significant increase in the membrane hydraulic permeability. The clearance of urea (MW=60 Da) increased by only 3% after a 1-hour exposure to bleach at 50°C compared to more than a 10-fold increase in the clearance of a 15 kD MW dextran. The solute clearance data were used to determine the effective membrane pore size using available hydrodynamic models. Bleach caused a significant increase in the effective pore size, which was attributed to the leaching of the polyvinylpyrrolidone (PVP) out of the polysulfone membrane. Bleach also caused a significant increase in the magnitude of the negative charge on the membrane surface; the zeta potential varied from -4.1 mV for the new membrane to -13.0 mV after a 14-hour exposure to bleach. These changes in pore size and surface properties provide important insights into the effects of bleach on hemodialysis membranes.

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