Effects of blood phase oscillation on gas transfer in a microporous intravascular lung

Kane High, T. Nicholson, R. B. Richard, G. R.J. Panol, K. Shelley, M. T. Snider

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

It may be possible to design an intravascular membrane lung with gas transfer properties augmented by the natural flow oscillations in the venous and pulmonary circulation caused by the beating heart and ventilatory movements. The authors used a simple dye visualization technique, the Pierce- Donachy assist pump, and mass spectrometry to investigate these effects on membrane lungs made with tethered, blind-ended, microporous, polypropylene fibers using in vitro tests in water saturated with O2, CO2, and He. Prototypes were constructed on a 7.5 Fr pulmonary artery catheter. The fibers had an outer diameter (OD) of 380 μm and a wall thickness of 50 μm and were mounted on 4.8 mm OD sleeves. Control measurements were taken over a range of steady water flows from 0.4 l/min to 3 l/min. While pumping the same water flow rates with a roller pump, the Pierce-Donachy pump generated pulsatile flow at a rate of 45 beats/min and a systolic duration of 300 msec. This produced a phasic flow with an instantaneous average flow velocity varying from 0 to as high as 46 cm/sec. O2 and CO2 transfer increased by as much as 91% and 59%, respectively. The largest effects were seen at the lower water flow rates.

Original languageEnglish (US)
JournalASAIO Journal
Volume40
Issue number3
DOIs
StatePublished - Jan 1 1994

Fingerprint

Blood
Gases
Lung
Water
Pumps
Flow rate
Membranes
Pulsatile Flow
Pulsatile flow
Pulmonary Circulation
Fibers
Polypropylenes
Catheters
Flow velocity
Pulmonary Artery
Mass spectrometry
Mass Spectrometry
Coloring Agents
Visualization
Dyes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

High, K., Nicholson, T., Richard, R. B., Panol, G. R. J., Shelley, K., & Snider, M. T. (1994). Effects of blood phase oscillation on gas transfer in a microporous intravascular lung. ASAIO Journal, 40(3). https://doi.org/10.1097/00002480-199407000-00096
High, Kane ; Nicholson, T. ; Richard, R. B. ; Panol, G. R.J. ; Shelley, K. ; Snider, M. T. / Effects of blood phase oscillation on gas transfer in a microporous intravascular lung. In: ASAIO Journal. 1994 ; Vol. 40, No. 3.
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High, K, Nicholson, T, Richard, RB, Panol, GRJ, Shelley, K & Snider, MT 1994, 'Effects of blood phase oscillation on gas transfer in a microporous intravascular lung', ASAIO Journal, vol. 40, no. 3. https://doi.org/10.1097/00002480-199407000-00096

Effects of blood phase oscillation on gas transfer in a microporous intravascular lung. / High, Kane; Nicholson, T.; Richard, R. B.; Panol, G. R.J.; Shelley, K.; Snider, M. T.

In: ASAIO Journal, Vol. 40, No. 3, 01.01.1994.

Research output: Contribution to journalArticle

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