Effects of chemopreventive selenium compounds on Jun N-kinase activities

Victor Adler, Matthew R. Pincus, Scott Posner, Pramod Upadhyaya, Karam El-Bayoumy, Ze'ev Ronai

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Activation of Jun-N-kinases (JNK) is stimulated by diverse agents including UV-irradiation, heat shock, tumor necrosis factor and osmotic shock. In the present study we have elucidated the effect of the organoselenium chemopreventive agent 1,4-phenylenebis(methylene)selenocyanate (p-XSC), on UV-mediated JNK activation. Using mouse fibroblasts as a model cell system we found that low concentrations (1-10 μM range) of p-XSC did not affect JNK activity, yet were capable of potentiating JNK activity when administered prior to UV-irradiation. While higher doses of p-XSC have minimal effect on JNK activation, when combined with UV, there is a dose-dependent decrease in JNK activation. Similar to its effects on JNK, p-XSC is a potent inducer of src-related tyrosine kinases. p-XSC mediated changes in JNK activation correlate with its ability to potentiate the association of JNK with p21(ras), in a manner similar to that we have previously observed with GTP or sodium vanadate. That p-XSC can modulate JNK activities points to a possible mechanism by which it contributes to the cell's ability to cope with stress.

Original languageEnglish (US)
Pages (from-to)1849-1854
Number of pages6
JournalCarcinogenesis
Volume17
Issue number9
DOIs
StatePublished - Sep 1996

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Selenium Compounds
Phosphotransferases
Proto-Oncogene Proteins p21(ras)
Vanadates
src-Family Kinases
Osmotic Pressure
Guanosine Triphosphate
Shock
Tumor Necrosis Factor-alpha
Fibroblasts
Hot Temperature

All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

Adler, V., Pincus, M. R., Posner, S., Upadhyaya, P., El-Bayoumy, K., & Ronai, Z. (1996). Effects of chemopreventive selenium compounds on Jun N-kinase activities. Carcinogenesis, 17(9), 1849-1854. https://doi.org/10.1093/carcin/17.9.1849
Adler, Victor ; Pincus, Matthew R. ; Posner, Scott ; Upadhyaya, Pramod ; El-Bayoumy, Karam ; Ronai, Ze'ev. / Effects of chemopreventive selenium compounds on Jun N-kinase activities. In: Carcinogenesis. 1996 ; Vol. 17, No. 9. pp. 1849-1854.
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Adler, V, Pincus, MR, Posner, S, Upadhyaya, P, El-Bayoumy, K & Ronai, Z 1996, 'Effects of chemopreventive selenium compounds on Jun N-kinase activities', Carcinogenesis, vol. 17, no. 9, pp. 1849-1854. https://doi.org/10.1093/carcin/17.9.1849

Effects of chemopreventive selenium compounds on Jun N-kinase activities. / Adler, Victor; Pincus, Matthew R.; Posner, Scott; Upadhyaya, Pramod; El-Bayoumy, Karam; Ronai, Ze'ev.

In: Carcinogenesis, Vol. 17, No. 9, 09.1996, p. 1849-1854.

Research output: Contribution to journalArticle

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