Effects of chronic methadone treatment on maternal body weight and food and water consumption in rats

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Body weight gain and food and water consumption of female rats receiving daily methadone injections (5 mg/kg) intraperitoneally prior to mating and during gestation and lactation were studied. In contrast to saline-injected mothers, methadone-treated females had lower body weights throughout pregnancy, but gained weight during lactation; by postnatal day 21, both groups were of comparable body weight. No significant differences in food consumption throughout gestation or lactation were recorded. Total water consumption of methadone-treated rats was higher during the first 2 weeks of gestation and lactation, and lower during the 3rd week of lactation when compared to controls. These results demonstrate that methadone-treated rats have lower body weights throughout gestation and lactation, and that these weight deficits are not caused by insufficient food and water consumption.

Original languageEnglish (US)
Pages (from-to)227-232
Number of pages6
JournalPharmacology
Volume17
Issue number4
DOIs
StatePublished - Jan 1 1978

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Body Water
Methadone
Lactation
Drinking
Body Weight
Mothers
Food
Pregnancy
Therapeutics
Weights and Measures
Weight Gain
Injections

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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abstract = "Body weight gain and food and water consumption of female rats receiving daily methadone injections (5 mg/kg) intraperitoneally prior to mating and during gestation and lactation were studied. In contrast to saline-injected mothers, methadone-treated females had lower body weights throughout pregnancy, but gained weight during lactation; by postnatal day 21, both groups were of comparable body weight. No significant differences in food consumption throughout gestation or lactation were recorded. Total water consumption of methadone-treated rats was higher during the first 2 weeks of gestation and lactation, and lower during the 3rd week of lactation when compared to controls. These results demonstrate that methadone-treated rats have lower body weights throughout gestation and lactation, and that these weight deficits are not caused by insufficient food and water consumption.",
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Effects of chronic methadone treatment on maternal body weight and food and water consumption in rats. / White, W. J.; McLaughlin, P. J.; Zagon, I. S.

In: Pharmacology, Vol. 17, No. 4, 01.01.1978, p. 227-232.

Research output: Contribution to journalArticle

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