Effects of chronic morphine administration on pregnant rats and their offspring

Research output: Contribution to journalArticle

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Abstract

The effect of chronic maternal morphine exposure on conception, pregnancy, and perinatal development was studied in rat. Beginning 5 days prior to mating and continuing through gestation and lactation, female Sprague-Dawley albino rats received twice daily intraperitoneal (i.p.) injections of morphine sulfate; drug dosages were gradually increased from 10 mg/kg/injection to a maintenance level of 40 mg/kg/injection. Throughout gestation, drug-treated mothers weighed less than saline-injected controls. Control females displayed progressive weight loss during lactation; morphine injected females showed marked weight gain in the 2nd and 3rd weeks of this period. Morphine administered during pregnancy produced decreased litter size, increased number of stillborns, increased infant mortality, and retardation of body growth in drug-exposed offspring. Weight deficits persisted in young rats observed 5 1/2 weeks after cessation of drug exposure as well as in animals continuing to receive twice daily i.p. injections of 20 mg/kg.

Original languageEnglish (US)
Pages (from-to)302-310
Number of pages9
JournalPharmacology
Volume15
Issue number4
DOIs
StatePublished - Jan 1 1977

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Morphine
Pregnancy
Intraperitoneal Injections
Lactation
Pharmaceutical Preparations
Maternal Exposure
Litter Size
Injections
Infant Mortality
Weight Gain
Sprague Dawley Rats
Weight Loss
Maintenance
Weights and Measures
Growth

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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Effects of chronic morphine administration on pregnant rats and their offspring. / Zagon, I. S.; McLaughlin, P. J.

In: Pharmacology, Vol. 15, No. 4, 01.01.1977, p. 302-310.

Research output: Contribution to journalArticle

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