Effects of dexamethasone and transient malnutrition on rabbits infected with aerosolized Mycobacterium tuberculosis CDC1551

Anup K. Kesavan, Susana E. Mendez, Christine L. Hatem, Javier Lopez-Molina, Katherine Aird, M. Louise M. Pitt, Arthur M. Dannenberg, Yukari C. Manabe

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12 Scopus citations

Abstract

Malnutrition is common in the developing world, where tuberculosis is often endemic. Rabbits infected with aerosolized Mycobacterium tuberculosis that subsequently became inadvertently and transiently malnourished had compromised cell-mediated immunity comparable to that of the rabbits immunosuppressed with dexamethasone. They had significant leukopenia and reduced delayed-type hypersensitivity responses. Malnutrition dampened cell-mediated immunity and would interfere with diagnostic tests that rely on intact CD4 T-cell responses.

Original languageEnglish (US)
Pages (from-to)7056-7060
Number of pages5
JournalInfection and Immunity
Volume73
Issue number10
DOIs
StatePublished - Oct 1 2005

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All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Kesavan, A. K., Mendez, S. E., Hatem, C. L., Lopez-Molina, J., Aird, K., Pitt, M. L. M., Dannenberg, A. M., & Manabe, Y. C. (2005). Effects of dexamethasone and transient malnutrition on rabbits infected with aerosolized Mycobacterium tuberculosis CDC1551. Infection and Immunity, 73(10), 7056-7060. https://doi.org/10.1128/IAI.73.10.7056-7060.2005