Effects of dietary restriction on motor learning and cerebellar noradrenergic dysfunction in aged F344 rats

Thomas J. Gould, Kathryn E. Bowenkamp, Gaynor Larson, Nancy R. Zahniser, Paula C. Bickford

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Fisher 344 rats were fed either ad libitum or with a diet containing a 40% reduction of calories beginning at 4 months of age. At 14 months and 22 months male rats were tested for their ability to learn a complex motor skill. At both ages the diet restricted rats reached criterion of performing 10 successful crosses in 10 min at an earlier time than ad libitum fed controls. At 22 months of age the diet restricted rats showed improved acquisition of running times for the task. Male rats at 14 and 22 months and female rats at 24 months were examined electrophysiologically frr the ability of isoproterenol to augment the action of GABA in the cerebellum when both substances were applied iontophoretically from an extracellular multibarreled glass electrode. In all 3 age and sex groups there was an improvement in the β-adrenergic receptor modulation of GABA responses in the dietary restricted vs. ad libtium rats. However, no difference was observed between dietary restricted and ad libitum rats when the number and affinity of cerebellar β-adrenergic receptors was assessed with125I-iodopindolol binding. Overall, there was a significant improvement in cerebellar noradrenergic function in the dietary restricted rats and this was accompanied by an improvement in motor learning.

Original languageEnglish (US)
Pages (from-to)150-158
Number of pages9
JournalBrain research
Volume684
Issue number2
DOIs
StatePublished - Jul 3 1995

Fingerprint

Cerebellar Diseases
Inbred F344 Rats
Learning
Aptitude
Diet
gamma-Aminobutyric Acid
Adrenergic Receptors
Motor Skills
Isoproterenol
Running
Cerebellum
Glass
Electrodes
Age Groups

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Gould, Thomas J. ; Bowenkamp, Kathryn E. ; Larson, Gaynor ; Zahniser, Nancy R. ; Bickford, Paula C. / Effects of dietary restriction on motor learning and cerebellar noradrenergic dysfunction in aged F344 rats. In: Brain research. 1995 ; Vol. 684, No. 2. pp. 150-158.
@article{b074d5b74a054d77829d3c891f1f4a20,
title = "Effects of dietary restriction on motor learning and cerebellar noradrenergic dysfunction in aged F344 rats",
abstract = "Fisher 344 rats were fed either ad libitum or with a diet containing a 40{\%} reduction of calories beginning at 4 months of age. At 14 months and 22 months male rats were tested for their ability to learn a complex motor skill. At both ages the diet restricted rats reached criterion of performing 10 successful crosses in 10 min at an earlier time than ad libitum fed controls. At 22 months of age the diet restricted rats showed improved acquisition of running times for the task. Male rats at 14 and 22 months and female rats at 24 months were examined electrophysiologically frr the ability of isoproterenol to augment the action of GABA in the cerebellum when both substances were applied iontophoretically from an extracellular multibarreled glass electrode. In all 3 age and sex groups there was an improvement in the β-adrenergic receptor modulation of GABA responses in the dietary restricted vs. ad libtium rats. However, no difference was observed between dietary restricted and ad libitum rats when the number and affinity of cerebellar β-adrenergic receptors was assessed with125I-iodopindolol binding. Overall, there was a significant improvement in cerebellar noradrenergic function in the dietary restricted rats and this was accompanied by an improvement in motor learning.",
author = "Gould, {Thomas J.} and Bowenkamp, {Kathryn E.} and Gaynor Larson and Zahniser, {Nancy R.} and Bickford, {Paula C.}",
year = "1995",
month = "7",
day = "3",
doi = "10.1016/0006-8993(95)00407-H",
language = "English (US)",
volume = "684",
pages = "150--158",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

Effects of dietary restriction on motor learning and cerebellar noradrenergic dysfunction in aged F344 rats. / Gould, Thomas J.; Bowenkamp, Kathryn E.; Larson, Gaynor; Zahniser, Nancy R.; Bickford, Paula C.

In: Brain research, Vol. 684, No. 2, 03.07.1995, p. 150-158.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of dietary restriction on motor learning and cerebellar noradrenergic dysfunction in aged F344 rats

AU - Gould, Thomas J.

AU - Bowenkamp, Kathryn E.

AU - Larson, Gaynor

AU - Zahniser, Nancy R.

AU - Bickford, Paula C.

PY - 1995/7/3

Y1 - 1995/7/3

N2 - Fisher 344 rats were fed either ad libitum or with a diet containing a 40% reduction of calories beginning at 4 months of age. At 14 months and 22 months male rats were tested for their ability to learn a complex motor skill. At both ages the diet restricted rats reached criterion of performing 10 successful crosses in 10 min at an earlier time than ad libitum fed controls. At 22 months of age the diet restricted rats showed improved acquisition of running times for the task. Male rats at 14 and 22 months and female rats at 24 months were examined electrophysiologically frr the ability of isoproterenol to augment the action of GABA in the cerebellum when both substances were applied iontophoretically from an extracellular multibarreled glass electrode. In all 3 age and sex groups there was an improvement in the β-adrenergic receptor modulation of GABA responses in the dietary restricted vs. ad libtium rats. However, no difference was observed between dietary restricted and ad libitum rats when the number and affinity of cerebellar β-adrenergic receptors was assessed with125I-iodopindolol binding. Overall, there was a significant improvement in cerebellar noradrenergic function in the dietary restricted rats and this was accompanied by an improvement in motor learning.

AB - Fisher 344 rats were fed either ad libitum or with a diet containing a 40% reduction of calories beginning at 4 months of age. At 14 months and 22 months male rats were tested for their ability to learn a complex motor skill. At both ages the diet restricted rats reached criterion of performing 10 successful crosses in 10 min at an earlier time than ad libitum fed controls. At 22 months of age the diet restricted rats showed improved acquisition of running times for the task. Male rats at 14 and 22 months and female rats at 24 months were examined electrophysiologically frr the ability of isoproterenol to augment the action of GABA in the cerebellum when both substances were applied iontophoretically from an extracellular multibarreled glass electrode. In all 3 age and sex groups there was an improvement in the β-adrenergic receptor modulation of GABA responses in the dietary restricted vs. ad libtium rats. However, no difference was observed between dietary restricted and ad libitum rats when the number and affinity of cerebellar β-adrenergic receptors was assessed with125I-iodopindolol binding. Overall, there was a significant improvement in cerebellar noradrenergic function in the dietary restricted rats and this was accompanied by an improvement in motor learning.

UR - http://www.scopus.com/inward/record.url?scp=0029054997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029054997&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(95)00407-H

DO - 10.1016/0006-8993(95)00407-H

M3 - Article

C2 - 7583216

AN - SCOPUS:0029054997

VL - 684

SP - 150

EP - 158

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -