Effects of domperidone therapy on symptoms and upper gastrointestinal motility in infants with gastroesophageal reflux

Bruce B. Grill, A. Craig Hillemeier, Lucille A. Semeraro, Richard W. McCallum, Joyce D. Gryboski

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

We evaluated the effect of domperidone, a novel prokinetic agent, on symptoms and esophageal and gastric motility in 15 infants (six boys), mean age 7.9 months, with moderate to severe gastroesophageal reflux (GER) and upper gastrointestinal motility disturbances. Patients received domperidone orally for 6 weeks and underwent weekly assessment of five GER-associated symptoms, weight change, and side effects. Mean total symptom scores significantly improved after treatment (P<0.01). Vomiting, "spitting," and coughing each improved significantly. Postprandial reflux time (defined as esophageal pH<4.0) and percent peristaltic esophageal contractions improved significantly (p<0.05). Gastric fundic contractions, present in only four infants before treatment, occurred in nine after domperidone administration. Although mean gastric emptying of isotope-labeled formula was not improved, it improved ≥10% over baseline in nine patients. Peristaltic amplitude, lower esophageal sphincter pressure, and esophageal acid clearance time were unchanged. Side effects were minimal. We conclude that domperidone is a useful and safe agent for treatment of gastroesophageal reflex in infants because it addresses the motility abnormalities inherent in the pathophysiology of the disorder.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalThe Journal of Pediatrics
Volume106
Issue number2
DOIs
StatePublished - Feb 1985

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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